Document Detail


Oral anticoagulant therapy in the primary and secondary prophylaxis of stroke.
MedLine Citation:
PMID:  14699705     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Stroke is the first cause of disability and the second cause of mortality in the world. Oral anticoagulants have been proved to be effective in the primary and secondary prophylaxis of stroke not only in cardiac conditions but also in other pathologies such as the antiphospholipid syndrome. Though the efficacy of oral anticoagulants in the prevention of stroke has been consolidated in several conditions such as mechanical prosthesis, atrial fibrillation, and the antiphospholipid syndrome, their role is less clear in patent foramen ovale, interatrial septal aneurysm, dilated cardiomyopathy, and aortic plaques. Nevertheless, oral anticoagulants have recently been re-evaluated in large clinical trials and have been shown to be effective in the secondary prevention of myocardial infarction and stroke. This review considers both the established and controversial aspects and the role of anticoagulation clinics in the practical approach to these patients, as well as their education and quality of life.
Authors:
Cristiana Cauli; Doris Barcellona; Francesco Marongiu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Italian heart journal : official journal of the Italian Federation of Cardiology     Volume:  4     ISSN:  1129-471X     ISO Abbreviation:  Ital Heart J     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-31     Completed Date:  2004-04-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100909716     Medline TA:  Ital Heart J     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  755-67     Citation Subset:  IM    
Affiliation:
Department of Internal Medical Sciences, University of Cagliari, Cagliari, Italy.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Anticoagulants / therapeutic use*
Antiphospholipid Syndrome / drug therapy,  epidemiology
Brain Ischemia / epidemiology,  prevention & control
Cardiovascular Diseases / drug therapy,  epidemiology
Europe / epidemiology
Humans
Incidence
Primary Prevention*
Risk Factors
Stroke / epidemiology,  prevention & control*
United States / epidemiology
Chemical
Reg. No./Substance:
0/Anticoagulants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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