Document Detail

Oral amino acid administration in patients with diabetes mellitus: supplementation or metabolic therapy?
MedLine Citation:
PMID:  15094101     Owner:  NLM     Status:  MEDLINE    
Amino acids are essential for body protein synthesis. Moreover, they can be used to produce energy within the cells. For protein turnover, normal plasma amino acid concentration enhances proteolytic suppression by insulin; furthermore, hyperaminoacidemia can stimulate protein synthesis both in the presence of baseline insulin and in hyperinsulinemic subjects with type 1 diabetes. In humans, the availability of amino acids represents a factor more important than insulin in maintaining protein synthesis in skeletal muscle. Among amino acids, branched-chain amino acids exert an anabolic effect on heart protein metabolism, and their uptake by the myocardium is increased by increasing their circulating concentrations. An important aspect of branched-chain amino acid metabolism in the heart (mainly in the ischemic heart) is that branch-chain amino acid infusion can diminish myocardial lactate; in this way, the inhibition of anaerobic energy phosphate caused by accumulation of lactate can be overridden. Plasma amino acid availability plays an important role in promoting protein synthesis and in energy production, both in peripheral skeletal muscle and in the myocardium.
Roberto Aquilani
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  93     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-05-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21A-22A     Citation Subset:  AIM; IM    
Service of Metabolic and Nutritional Pathophysiology, Salvatore Maugeri Foundation, IRCCS, Medical Center of Montescano, Pavia, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Oral
Amino Acids, Essential / administration & dosage*
Diabetes Mellitus / diet therapy*
Dietary Supplements*
Reg. No./Substance:
0/Amino Acids, Essential

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Early myocardial dysfunction in the diabetic heart: current research and clinical applications.
Next Document:  Metabolic effects of orally administered amino acid mixture in elderly subjects with poorly controll...