Document Detail

Oral administration of yeast, Saccharomyces cerevisiae, enhances the cellular innate immune response of gilthead seabream (Sparus aurata L.).
MedLine Citation:
PMID:  11867166     Owner:  NLM     Status:  MEDLINE    
The effects of including lyophilised whole yeast, Saccharomyces cerevisiae, in the diet on the seabream innate immune response were investigated. Gilthead seabream (Sparus aurata L.) specimens were fed four different diets for 4 weeks: a commercial diet as control and the same diet supplemented with 1, 5 or 10 g/kg yeast. After 1, 2 and 4 weeks, serum complement titres, as a humoral parameter, and phagocytic, respiratory burst, myeloperoxidase and natural cytotoxic activities of head-kidney leucocytes, as cellular parameters, were evaluated. The results showed that yeast supplements enhanced all the latter responses, but not the humoral response. This enhancement was dose-dependent except for the cytotoxic activity that was only stimulated by the lower dose of yeast assayed. As yeast cell walls are able to enhance the seabream cellular innate immune response, these results support the possible use of whole yeast as natural inmunostimulants in common fish diets.
Jesús Ortuño; Alberto Cuesta; Alejandro Rodríguez; M Angeles Esteban; José Meseguer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary immunology and immunopathology     Volume:  85     ISSN:  0165-2427     ISO Abbreviation:  Vet. Immunol. Immunopathol.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-27     Completed Date:  2002-04-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8002006     Medline TA:  Vet Immunol Immunopathol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-50     Citation Subset:  IM    
Faculty of Biology, Department of Cell Biology, University of Murcia, 30071, Murcia, Spain.
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MeSH Terms
Adjuvants, Immunologic / pharmacology*
Administration, Oral
Complement System Proteins / physiology
Cytotoxicity, Immunologic
Immunity, Innate*
Peroxidase / metabolism
Respiratory Burst
Saccharomyces cerevisiae / immunology*
Sea Bream / immunology*
Reg. No./Substance:
0/Adjuvants, Immunologic; 9007-36-7/Complement System Proteins; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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