| Oral administration of stavudine induces hyperalgesia without affecting activity in rats. | |
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MedLine Citation:
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PMID: 17632188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have investigated whether long-term oral administration of the nucleoside reverse transcriptase inhibitor (NRTI) stavudine affects nociception in Sprague-Dawley rats, and whether any changes of nociception are accompanied by deterioration in activity and appetite. Stavudine (50 mg kg(-1)) was administered to rats orally once daily for six weeks in gelatine cubes. Mechanical hyperalgesia of the tail was assessed using a bar algometer, and thermal hyperalgesia by tail immersion in 49 degrees C water. Withdrawal latencies were compared to those of rats receiving placebo gelatine cubes. Withdrawal latencies to the noxious thermal challenge were not affected by stavudine, but those to the mechanical challenge were significantly decreased in rats receiving stavudine, compared to rats receiving placebo, from week three to week six of drug administration (P<0.05, ANCOVA with Newman Keuls post-hoc comparisons). The overall condition of the rats was assessed by recording daily voluntary wheel running distance and maximum running speed, food intake and body mass. Daily stavudine administration did not adversely affect voluntary running activity, appetite or growth. We have shown that long-term daily oral administration of the NRTI stavudine results in mechanical hyperalgesia in rats within three weeks without affecting appetite, growth and physical activity. |
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Authors:
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Juliane Weber; Duncan Mitchell; Peter R Kamerman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-14 |
Journal Detail:
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Title: Physiology & behavior Volume: 92 ISSN: 0031-9384 ISO Abbreviation: Physiol. Behav. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-20 Completed Date: 2008-02-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 807-13 Citation Subset: IM |
Affiliation:
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Brain Function Research Group, School of Physiology, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown, Gauteng, South Africa, 2193. juliane9@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Analysis of Variance Animals Antimetabolites / administration & dosage* Behavior, Animal / drug effects Body Mass Index Body Weight / drug effects Eating / drug effects Female Hyperalgesia / chemically induced* Motor Activity / drug effects* Pain Measurement Physical Stimulation Rats Rats, Sprague-Dawley Reaction Time / drug effects Running Stavudine / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 3056-17-5/Stavudine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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