| Oral administration of short-chain fatty acids reduces the intestinal mucositis caused by treatment with Ara-C in mice fed commercial or elemental diets. | |
| | |
MedLine Citation:
|
PMID: 9290130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Swiss mice fed commercial or elemental diets and an oral short-chain fatty acid (SCFA) solution or saline were treated with the cytostatic drug Ara-C (cytarabine, 3.6 mg/mouse/day) for two or four days. Histopathological examination revealed less damage (atrophy, inflammation, or necrosis) to the small intestine and colon caused by Ara-C when SCFA was administered. Accordingly, protein and nucleotide concentrations in the intestinal mucosa were higher in the group receiving SCFA than in the group receiving a placebo of the same pH and osmolarity. Improvement by SCFA treatment was correlated with an increase in the height of the intestinal villi, with no alterations of the crypts. Furthermore, the number of intraepithelial lymphocytes was similar to normal values in animals receiving SCFA and Ara-C. When large doses of SCFA were administered, xanthomized enterocytes appeared, suggesting an accumulation of fatty acids in these cells. We conclude that oral administration of SCFA at close to physiological proportions reduces the inflammation and necrosis caused by Ara-C administration, thus representing a potential factor for the improvement of patients with mucositis caused by cancer treatment. |
| | |
Authors:
|
M G Ramos; E A Bambirra; D C Cara; E C Vieira; J I Alvarez-Leite |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Nutrition and cancer Volume: 28 ISSN: 0163-5581 ISO Abbreviation: Nutr Cancer Publication Date: 1997 |
Date Detail:
|
Created Date: 1997-12-17 Completed Date: 1997-12-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7905040 Medline TA: Nutr Cancer Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 212-7 Citation Subset: IM |
Affiliation:
|
Departamento de Bioquímica e Immunologia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Antimetabolites, Antineoplastic / administration & dosage, toxicity* Cohort Studies Cytarabine / administration & dosage, toxicity* Diet Fatty Acids, Volatile / administration & dosage, therapeutic use* Inflammation / chemically induced, drug therapy, pathology Intestinal Diseases / chemically induced, drug therapy*, pathology Intestinal Mucosa / drug effects, pathology* Intestine, Small / chemistry, drug effects Mice Nucleotides / analysis |
| Chemical | |
Reg. No./Substance:
|
0/Antimetabolites, Antineoplastic; 0/Fatty Acids, Volatile; 0/Nucleotides; 147-94-4/Cytarabine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin B6 suppresses growth and expression of albumin gene in a human hepatoma cell line HepG2.
Next Document: Prenatal theophylline and necrotizing enterocolitis in premature newborn infants.