Document Detail

Oral administration of glucose promotes intracellular partitioning of fatty acid toward storage in white but not in red muscle.
MedLine Citation:
PMID:  17003266     Owner:  NLM     Status:  MEDLINE    
Lipid accumulation in non-adipose tissues is strongly associated with the metabolic syndrome, possibly due to aberrant partitioning of intracellular fatty acids between storage and oxidation. In the present study, we administered the non-metabolizable fatty acid analog [9,10-(3)H]-(R)-2-bromopalmitate, and authentic (14)C-palmitate to conscious rats, in order to directly examine the initial intracellular fate of fatty acids in a range of insulin-sensitive tissues, including white and red muscles, liver, white adipose tissue, and heart. Rats were studied after administration of an oral glucose load to examine the effect of physiological elevation of glucose and insulin. The tracer results showed that glucose administration partitioned fatty acid toward storage in white muscle (storage:uptake ratios, vehicle vs glucose; 0.64 +/- 0.02 vs 0.92 +/- 0.09, P < 0.05), and in liver (0.66 +/- 0.07 vs 0.98 +/- 0.04, P < 0.05), but not in red muscle (1.18 +/- 0.07 vs 1.36 +/- 0.11, P = not significant). These results demonstrate the physiological relevance of the so-called 'reverse' Randle cycle, but surprisingly show that it may be more important in white rather than oxidative red muscle.
Keld Fosgerau; Christian Fledelius; Kent E Pedersen; Jesper B Kristensen; Jens R Daugaard; Miguel A Iglesias; Edward W Kraegen; Stuart M Furler
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  190     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-27     Completed Date:  2006-12-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  651-8     Citation Subset:  IM    
In vivo Pharmacology, Rheoscience, Ledøje Bygade 23B, DK-2765 Ledøje-Smørum, Denmark.
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MeSH Terms
Adipose Tissue / metabolism
Administration, Oral
Blood Glucose / analysis
Carbon Isotopes
Fatty Acids / metabolism*
Fatty Acids, Nonesterified / blood
Glucose / administration & dosage*
Glucose Tolerance Test
Glycerol / blood
Insulin / metabolism
Insulin Resistance*
Lipid Metabolism
Liver / metabolism
Metabolic Clearance Rate
Muscle Fibers, Fast-Twitch / metabolism*
Myocardium / metabolism
Palmitates / administration & dosage,  metabolism
Rats, Sprague-Dawley
Reg. No./Substance:
0/Blood Glucose; 0/Carbon Isotopes; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Palmitates; 11061-68-0/Insulin; 50-99-7/Glucose; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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