Document Detail

Oral administration of docosahexaenoic acid/eicosapentaeinoic acids is not anticonvulsant in rats: implications for translational research.
MedLine Citation:
PMID:  21857379     Owner:  NLM     Status:  Publisher    
Omega-3 and omega-6 poly-unsaturated fatty acids (PUFA) are dietary fatty acids that are involved in a myriad of physiological processes in the brain. While experimental data have shown that PUFA have anticonvulsant properties, the outcomes of clinical trials have been controversial. Docosahexaenoic acid (DHA) is a PUFA which has been reported to exert anticonvulsant effects. Here we studied anticonvulsant potential of a mixture of enriched n-3 PUFA upon their oral administration in rats. We did not observe an anticonvulsant effect of n-3 PUFA in the i.v. pentylentetrazol threshold test. n-3 PUFA component was increased in the plasma of rats treated with the eicosapentaenoic acid (EPA)/DHA mix (275mg/kg/d/400mg/kg/d) due to the increase of both DHA and of EPA. We also found modification of PUFA composition in the brain. Despite PUFA profiles were modified both in plasma and in the brain, we did not find any anticonvulsant effect of orally administered DHA. Further studies are needed to define the type and the amount of fatty acid(s) that would possess anticonvulsant properties. Since the existing literature suggests that the route of administration of PUFA may be crucial, future studies should involve oral administration in order to provide relevant clinical information. ABBREVIATIONS::
Niccolo Curatolo; Cécile Lecointe; Regis Bordet; Louis Vallée; Claude Galabert; Pierre Gressens; Stéphane Auvin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-18
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Inserm U676, [N.C., C.L., P.G., S.A.], Université Paris 7 75019 Paris, France; Service de Neurologie Pédiatrique [S.A.], Hôpital Robert Debré, 75019, Paris, France; Department of Pharmacology [R.B., L.V.], Institut de Médecine Prédictive et de Recherche Thérapeutique, Université de Lille-2, 59000 Lille, France; CERM [C.G.], Hôpital Renée Sabran, 83406 Giens Hyères, CHU Lyon, France.
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