| Oral administration of cyclosporin A for recipients of allogeneic marrow transplants: implications of clinical gut dysfunction. | |
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MedLine Citation:
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PMID: 6362711 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cyclosporin A (CyA) was used to minimize graft-versus-host disease (GVHD) in 28 recipients of allogeneic marrow transplants. When given orally, the absorption of CyA was markedly dependent on normal gut function. Patients without gut dysfunction showed normal serum concentration-time curves while those with diarrhoea from any cause (chemo-radiation enteritis, acute GVHD of the gut, infectious enteritis) showed minimal absorption of the drug. These data indicate the desirability of the intravenous administration of CyA during periods of gut dysfunction in marrow transplant recipients. |
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Authors:
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K Atkinson; J C Biggs; K Britton; R Short; R Mrongovius; A Concannon; A Dodds |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British journal of haematology Volume: 56 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-03-19 Completed Date: 1984-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 223-31 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Anemia, Aplastic / therapy Bone Marrow Transplantation* Cyclosporins / administration & dosage*, blood Diarrhea / blood, etiology Enteritis / blood Graft vs Host Disease / blood Humans Infusions, Parenteral Intestinal Absorption Leukemia / therapy Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Cyclosporins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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