Document Detail

Oral administration of IL-12 abrogates the induction but not the maintenance of oral tolerance.
MedLine Citation:
PMID:  16741366     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: IL-12 is a Th1-inducing cytokine and known to be induced by some food factors. This function of such foods is expected to be applied for antiallergic materials. However, the influence of IL-12 on the immune responses has not been fully investigated. Oral tolerance is an immunologically unresponsive state induced by orally administered food antigens. Although a failure in the induction of oral tolerance would result in food allergy, the mechanisms for the induction and abrogation of oral tolerance have not been clarified. IL-12 induced by food factors may also affect the induction of oral tolerance. In this study we examined the effect of the oral administration of IL-12 on the induction and maintenance of oral tolerance. METHODS: BALB/c mice were fed beta-lactoglobulin with or without IL-12. After immunizing them with the antigen, the serum antibody titer of these mice was measured to evaluate the induction of oral tolerance. RESULTS: The induction of oral tolerance was prevented in the mice that had been simultaneously fed the antigen and IL-12. On the other hand IL-12 did not abrogate the already established oral tolerance when it was administered after feeding the antigen. We also found that oral tolerance could be induced normally in mice that had failed to induce such tolerance by simultaneous feeding of IL-12 and the antigen. CONCLUSIONS: The results indicate that IL-12 induced in the intestine by some food factors is involved in the regulation of oral tolerance.
Tadashi Yoshida; Tsukasa Uno; Aki Hirano; Hanae Wada; Koji Takahashi; Makoto Hattori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-06-01
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  140     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  306-14     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
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MeSH Terms
Administration, Oral
Antibody Formation / drug effects
Clonal Anergy / drug effects,  immunology
Coculture Techniques
Dietary Proteins / administration & dosage,  immunology
Epitopes, B-Lymphocyte / immunology
Immune Tolerance / drug effects*
Immunoglobulin G / blood
Interleukin-12 / administration & dosage,  pharmacology*
Lactoglobulins / administration & dosage,  immunology
Lymph Nodes / cytology,  drug effects,  immunology
Lymphocyte Activation / drug effects,  immunology
Mice, Inbred BALB C
Spleen / cytology,  drug effects,  immunology
T-Lymphocytes / drug effects,  immunology
Reg. No./Substance:
0/Dietary Proteins; 0/Epitopes, B-Lymphocyte; 0/Immunoglobulin G; 0/Lactoglobulins; 187348-17-0/Interleukin-12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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