Document Detail

Oral administration of Antioxidant Biofactor (AOBtrade mark) ameliorates ischemia/reperfusion- induced neuronal death in the gerbil.
MedLine Citation:
PMID:  17673828     Owner:  NLM     Status:  MEDLINE    
Oxidative damage due to ischemia/reperfusion has been implicated as one of the leading causes for delayed neuronal cell death in a number of neurodegenerative diseases, including stroke. The purpose of this research was to investigate whether oral administration of a fermented grain food mixture (AOB(R)) might offer protective effects against ischemia/reperfusion-induced neuronal damage in Mongolian gerbils, a model known for delayed neuronal death in the hippocampal CA1 region. Histological analysis revealed that AOB administration ad libitum for 3 weeks (preoperative administration) and 1 week (postoperative administration) dose-dependently suppressed the induction of transient ischemia/reperfusion-induced neuronal cell death. TUNEL assay also revealed that AOB suppressed it by inhibiting the induction of apoptosis. A significant increase of superoxide dismutase-like (SOD-like) activity was observed in the hippocampal CA1 region of the AOB-treated gerbil. Furthermore, immunoblot analysis showed that AOB administration down-regulated the expression of heat shock proteins HSP27 and HSP70 in the same region. These results indicated that oral administration of AOB protected against ischemia/reperfusion-induced brain injury by minimizing oxidative damage via its SOD-like activity and inhibiting apoptosis.
Hironobu Yasui; Taketoshi Asanuma; Yasuko Watanabe; Kenji Waki; Osamu Inanami; Mikinori Kuwabara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  29     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-03     Completed Date:  2007-11-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  113-21     Citation Subset:  IM    
Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
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MeSH Terms
Administration, Oral
Apoptosis / drug effects*
Body Weight / drug effects
Brain Ischemia / pathology
Eating / drug effects
Heat-Shock Proteins / metabolism
Hippocampus / drug effects,  pathology
Neurons / pathology*
Phenols / administration & dosage,  therapeutic use*
Plant Extracts / administration & dosage,  therapeutic use*
Reperfusion Injury / prevention & control*
Superoxide Dismutase / metabolism
Reg. No./Substance:
0/Heat-Shock Proteins; 0/Phenols; 0/Plant Extracts; 0/antioxidant biofactor AOB; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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