| Oral administration of Antioxidant Biofactor (AOBtrade mark) ameliorates ischemia/reperfusion- induced neuronal death in the gerbil. | |
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MedLine Citation:
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PMID: 17673828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Oxidative damage due to ischemia/reperfusion has been implicated as one of the leading causes for delayed neuronal cell death in a number of neurodegenerative diseases, including stroke. The purpose of this research was to investigate whether oral administration of a fermented grain food mixture (AOB(R)) might offer protective effects against ischemia/reperfusion-induced neuronal damage in Mongolian gerbils, a model known for delayed neuronal death in the hippocampal CA1 region. Histological analysis revealed that AOB administration ad libitum for 3 weeks (preoperative administration) and 1 week (postoperative administration) dose-dependently suppressed the induction of transient ischemia/reperfusion-induced neuronal cell death. TUNEL assay also revealed that AOB suppressed it by inhibiting the induction of apoptosis. A significant increase of superoxide dismutase-like (SOD-like) activity was observed in the hippocampal CA1 region of the AOB-treated gerbil. Furthermore, immunoblot analysis showed that AOB administration down-regulated the expression of heat shock proteins HSP27 and HSP70 in the same region. These results indicated that oral administration of AOB protected against ischemia/reperfusion-induced brain injury by minimizing oxidative damage via its SOD-like activity and inhibiting apoptosis. |
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Authors:
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Hironobu Yasui; Taketoshi Asanuma; Yasuko Watanabe; Kenji Waki; Osamu Inanami; Mikinori Kuwabara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: 29 ISSN: 0951-6433 ISO Abbreviation: Biofactors Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-03 Completed Date: 2007-11-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: Netherlands |
Other Details:
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Languages: eng Pagination: 113-21 Citation Subset: IM |
Affiliation:
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Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Apoptosis / drug effects* Body Weight / drug effects Brain Ischemia / pathology Eating / drug effects Gerbillinae Heat-Shock Proteins / metabolism Hippocampus / drug effects, pathology Male Neurons / pathology* Phenols / administration & dosage, therapeutic use* Plant Extracts / administration & dosage, therapeutic use* Reperfusion Injury / prevention & control* Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Heat-Shock Proteins; 0/Phenols; 0/Plant Extracts; 0/antioxidant biofactor AOB; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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