Document Detail

Oral acyclovir in the treatment of herpes zoster in general practice.
MedLine Citation:
PMID:  2648213     Owner:  NLM     Status:  MEDLINE    
A double-blind, randomised trial evaluated the efficacy of oral acyclovir, 800 mg 5 times daily for 7 days, in acute herpes zoster and postherpetic neuralgia. Forty patients aged 16 years or over, presenting to their general practitioners within 3 days of rash onset, received acyclovir, while 43 patients received placebo. Acyclovir reduced the extent and duration of the rash, the spread of the rash to adjacent dermatomes and the incidence of disseminated lesions. It shortened the period of new lesion formation and reduced the incidence of ulceration. The weekly prevalence of pain was reduced on acyclovir by the fourth week, with a reduction in the monthly prevalence of chronic pain in the second and third months and a reduction in associated local neurological symptoms between months 3-6. Total analgesic use in the first 4 weeks was reduced by acyclovir, but during follow up there was no difference in the prevalence of analgesic use between groups. There were slightly fewer medical events on acyclovir in the second week, but the frequency was the same in each group for the rest of the 6 months. Biochemical and haematological tests showed no adverse effects of treatment.
P Morton; A N Thomson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The New Zealand medical journal     Volume:  102     ISSN:  0028-8446     ISO Abbreviation:  N. Z. Med. J.     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-21     Completed Date:  1989-04-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0401067     Medline TA:  N Z Med J     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  93-5     Citation Subset:  IM    
Wellcome New Zealand Ltd, Auckland.
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MeSH Terms
Acute Disease
Acyclovir / administration & dosage*,  therapeutic use
Administration, Oral
Aged, 80 and over
Analgesics / administration & dosage
Clinical Trials as Topic
Double-Blind Method
Drug Administration Schedule
Family Practice*
Follow-Up Studies
Herpes Zoster / complications,  drug therapy*
Middle Aged
Neuralgia / drug therapy*,  etiology
Random Allocation
Reg. No./Substance:
0/Analgesics; 0/Tablets; 59277-89-3/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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