| Oral acyclovir in the treatment of herpes zoster in general practice. | |
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MedLine Citation:
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PMID: 2648213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind, randomised trial evaluated the efficacy of oral acyclovir, 800 mg 5 times daily for 7 days, in acute herpes zoster and postherpetic neuralgia. Forty patients aged 16 years or over, presenting to their general practitioners within 3 days of rash onset, received acyclovir, while 43 patients received placebo. Acyclovir reduced the extent and duration of the rash, the spread of the rash to adjacent dermatomes and the incidence of disseminated lesions. It shortened the period of new lesion formation and reduced the incidence of ulceration. The weekly prevalence of pain was reduced on acyclovir by the fourth week, with a reduction in the monthly prevalence of chronic pain in the second and third months and a reduction in associated local neurological symptoms between months 3-6. Total analgesic use in the first 4 weeks was reduced by acyclovir, but during follow up there was no difference in the prevalence of analgesic use between groups. There were slightly fewer medical events on acyclovir in the second week, but the frequency was the same in each group for the rest of the 6 months. Biochemical and haematological tests showed no adverse effects of treatment. |
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Authors:
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P Morton; A N Thomson |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The New Zealand medical journal Volume: 102 ISSN: 0028-8446 ISO Abbreviation: N. Z. Med. J. Publication Date: 1989 Mar |
Date Detail:
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Created Date: 1989-04-21 Completed Date: 1989-04-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401067 Medline TA: N Z Med J Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 93-5 Citation Subset: IM |
Affiliation:
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Wellcome New Zealand Ltd, Auckland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Acyclovir / administration & dosage*, therapeutic use Administration, Oral Adolescent Adult Aged Aged, 80 and over Analgesics / administration & dosage Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Family Practice* Female Follow-Up Studies Herpes Zoster / complications, drug therapy* Humans Male Middle Aged Neuralgia / drug therapy*, etiology Random Allocation Tablets |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Tablets; 59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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