| Oral activity of FMRFamide-related peptides on the pea aphid Acyrthosiphon pisum (Hemiptera: Aphididae) and degradation by enzymes from the aphid gut. | |
| | |
MedLine Citation:
|
PMID: 21704083 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Insect myosuppressins and myosuppressin analogues were tested for oral toxicity against the pea aphid Acyrthosiphon pisum (Harris) by incorporation into an artificial diet. Acyrthosiphon pisum myosuppressin (Acypi-MS) and leucomyosuppressin (LMS) had significant dose-dependent effects (0.1-0.5μg peptide/μl diet) on feeding suppression, mortality, reduced growth and fecundity compared with control insects, but Acypi-MS was more potent than LMS. One hundred percent of aphids had died after 10days of feeding on 0.5μg Acypi-MS/μl diet whereas 40% of aphids feeding on 0.5μg LMS/μl diet were still alive after 13days. Myosuppressins were degraded by aphid gut enzymes; degradation was most likely due to a carboxypeptidase-like protease, an aminopeptidase and a cathepsin L cysteine protease. The estimated half-life of Acypi-MS in a gut extract was 30min, whereas LMS was degraded more slowly (t½=54min). No toxicity was observed when the analogues δR(9) LMS and citrolline(9) Acypi-MS or FMRFamide were fed to the pea aphid. These findings not only help to better understand the biological effects of myosuppressins in aphids but also demonstrate the potential use of myosuppressins in a strategy to control aphid pests. |
| | |
Authors:
|
Rachel E Down; H June Matthews; Neil Audsley |
Related Documents
:
|
1306093 - Folate, vitamin c, and cervical intraepithelial neoplasia. 17050573 - Parallel changes in metabolite and expression profiles in crooked-tail mutant and folat... 9788253 - Dietary modification of high density lipoprotein phospholipid and influence on cellular... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-22 |
Journal Detail:
|
Title: Regulatory peptides Volume: - ISSN: 1873-1686 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8100479 Medline TA: Regul Pept Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Crown Copyright © 2011. Published by Elsevier B.V. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Kinematics of obstacle clearance in the rat.
Next Document: Improvement of phylum- and class-specific primers for real-time PCR quantification of bacterial taxa...