Document Detail


Oral topiramate in neonates with hypoxic ischemic encephalopathy treated with hypothermia: a safety study.
MedLine Citation:
PMID:  20553846     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate whether topiramate associated with mild or deep hypothermia in asphyxiated term infants is safe in relation to the short-term outcome.
STUDY DESIGN: We report on 27 consecutive asphyxiated newborns who were treated with whole body hypothermia and 27 additional consecutive newborns with hypothermia who were co-treated with oral topiramate, once a day for 3 consecutive days, at 2 different doses.
RESULTS: Newborns were divided in 6 groups according to the depth of hypothermia and the association with higher or lower topiramate dosage. A statistical comparison of the groups identified some differences in biochemical and hemodynamic variables, but no adverse effects attributable to topiramate were detected. There were no statistically significant differences in the groups in short-term outcomes, survival rate at discharge, or incidence of pathologic brain magnetic resonance imaging.
CONCLUSION: Although the number of newborns in this study was limited, the short-term outcome and the safety data appear to support the evaluation of topiramate in clinical trials to explore its possible additive neuroprotective action.
Authors:
Luca Filippi; Chiara Poggi; Giancarlo la Marca; Sandra Furlanetto; Patrizio Fiorini; Giacomo Cavallaro; Angela Plantulli; Gianpaolo Donzelli; Renzo Guerrini
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-05-31
Journal Detail:
Title:  The Journal of pediatrics     Volume:  157     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-23     Completed Date:  2010-09-23     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright (c) 2010 Mosby, Inc. All rights reserved.
Affiliation:
Neonatal Intensive Care Unit, Department of Critical Care Medicine, A. Meyer University Children's Hospital, and Department of Pharmacology, University of Florence, Florence, Italy. l.filippi@meyer.it
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Combined Modality Therapy
Female
Fructose / administration & dosage,  analogs & derivatives*
Humans
Hypothermia, Induced*
Hypoxia-Ischemia, Brain / therapy*
Infant, Newborn
Male
Neuroprotective Agents / administration & dosage*
Retrospective Studies
Chemical
Reg. No./Substance:
0/Neuroprotective Agents; 0H73WJJ391/topiramate; 30237-26-4/Fructose
Comments/Corrections
Comment In:
J Pediatr. 2010 Sep;157(3):351-2   [PMID:  20659738 ]

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