Document Detail

Oral Tolerance Induction for Human Food Allergy.
MedLine Citation:
PMID:  22280235     Owner:  NLM     Status:  Publisher    
Food allergies are classified as IgE-mediated and non-IgE mediated type. The number of successful reports of immunotherapy, namely tolerance induction for food allergy (TIFA) are increasing, bringing hope for meaningful positive and radical treatment of food allergy. Therapeutic characteristics of the clinical course in TIFA for NFA are different from TIFA for IFA. Cytokines including IL-10, TGF-β and IFN-γ and regulatory cells such as Treg and Breg, are involved in immune tolerance. IFN-γ has been used for tolerance induction of food allergy as an immunomodulatory biologics. A definitive distinction between IgE-mediated and non-IgE-mediated food allergies is absolutely essential for diagnostic and therapeutic purposes. Original SOTI using IFN-γ is more effective than conventional SOTI without IFN-γ. Especially, IFN-γ is absolutely necessary for the tolerance induction of NFA. This review highlights and updates the advances in the conceptual immunological background and the clinical characteristics of oral tolerance induction for food allergy.
Geunwoong Noh
Related Documents :
6794365 - Effects of food on valproic acid absorption.
10102975 - Impact of food intake on the antisecretory effect of low-dose ranitidine and famotidine.
12885395 - Oral bioavailability of the antioxidant astaxanthin in humans is enhanced by incorporat...
2920505 - Effects of time of dose in relation to food on the bioavailability of theo-dur sprinkle...
17094705 - Conditions of transfer and quality of food.
6794365 - Effects of food on valproic acid absorption.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-20
Journal Detail:
Title:  Inflammation & allergy drug targets     Volume:  -     ISSN:  2212-4055     ISO Abbreviation:  Inflamm Allergy Drug Targets     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101266886     Medline TA:  Inflamm Allergy Drug Targets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Subdivision of Allergy and Clinical Immunology, Department of Paediatrics, Chungnam National University Hospital, 33 Munwha-ro, Jung-gu, Daejeon, Republic of Korea 301-721.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhaled antibiotics for nosocomial pneumonia.
Next Document:  The IL23/Th17 pathway as a therapeutic target in chronic inflammatory diseases.