Document Detail

Oral Proliferative Verrucous Leukoplakia: are there particular features for such an ambiguous entity? Systematic review.
MedLine Citation:
PMID:  24471527     Owner:  NLM     Status:  Publisher    
Proliferative verrucous leukoplakia (PVL) is a distinct, particularly aggressive form of oral leukoplakia. Given the low prevalence of PVL, data are sparse and are usually extrapolated from case reports, case series and only a few case-control studies, meaning that literature is able to provide only weak evidence. The present systematic literature review aims at collating the available evidence on the following issues: patient demographics, aetiology, lesion location/s, malignant potential, location and histopathological features of transformed lesions, disease specific survival-rate and treatment response. Electronic databases were searched for studies in the English-language reporting original data from at least 10 PVL patients on the target issues of the present review. The retrieved data were merged and a descriptive analysis performed. The 20 studies selected indicated that PVL does not seem to be correlated to the major risk factors for oral carcinoma (tobacco, alcohol and/or areca nut/betel leaf chewing). The disorder mainly affects adult/elderly females and has a very high malignant transformation rate, particular site distribution and particular location and histopathological features of transformed lesions. The present results may be limited by: some articles being unintentionally excluded as they were not found during the electronic search, lack of worldwide accepted diagnostic criteria for PVL, overlapping data from multiple studies performed in a limited number of centres. Despite these potential drawbacks, the present results evidence the fact that PVL do have particular features. This article is protected by copyright. All rights reserved.
M Pentenero; M Meleti; P Vescovi; S Gandolfo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-28
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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