Document Detail

Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment.
MedLine Citation:
PMID:  20739445     Owner:  NLM     Status:  MEDLINE    
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), (n-3) fatty acids from fish oil, have immune-modulating effects and may improve nutritional status in cancer. The objective of this study was to investigate the effects of an oral nutritional supplement containing (n-3) fatty acids on nutritional status and inflammatory markers in patients with non-small cell lung cancer (NSCLC) undergoing multimodality treatment. In a double-blind experiment, 40 patients with stage III NSCLC were randomly assigned to receive 2 cans/d of a protein- and energy-dense oral nutritional supplement containing (n-3) fatty acids (2.0 g EPA + 0.9 g DHA/d) or an isocaloric control supplement. EPA in plasma phospholipids, energy intake, resting energy expenditure (REE), body weight, fat free mass (FFM), mid-upper arm circumference (MUAC), and inflammatory markers were assessed. Effects of intervention were analyzed by generalized estimating equations and expressed as regression coefficients (B). The intervention group (I) had a better weight maintenance than the control (C) group after 2 and 4 wk (B = 1.3 and 1.7 kg, respectively; P < 0.05), a better FFM maintenance after 3 and 5 wk (B = 1.5 and 1.9 kg, respectively; P < 0.05), a reduced REE (B = -16.7% of predicted; P = 0.01) after 3 wk, and a trend for a greater MUAC (B = 9.1; P = 0.06) and lower interleukin-6 production (B = -27.9; P = 0.08) after 5 wk. After 4 wk, the I group had a higher energy and protein intake than the C group (B = 2456 kJ/24 h, P = 0.03 and B = 25.0 g, P = 0.01, respectively). In conclusion, a protein- and energy-dense oral nutritional supplement containing (n-3) fatty acids beneficially affects nutritional status during multimodality treatment in patients with NSCLC.
Barbara S van der Meij; Jacqueline A E Langius; Egbert F Smit; Marieke D Spreeuwenberg; B Mary E von Blomberg; Annemieke C Heijboer; Marinus A Paul; Paul A M van Leeuwen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-08-25
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1774-80     Citation Subset:  IM    
Department of Nutrition and Dietetics, Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Biological Markers / blood
Carcinoma, Non-Small-Cell Lung / therapy*
Combined Modality Therapy
Dietary Proteins / administration & dosage
Dietary Supplements
Double-Blind Method
Eicosapentaenoic Acid / blood
Energy Intake
Energy Metabolism
Fatty Acids, Omega-3 / administration & dosage*
Inflammation / blood
Lung Neoplasms / therapy*
Middle Aged
Neoplasm Staging
Nutritional Status / drug effects*
Patient Compliance
Phospholipids / blood
Reg. No./Substance:
0/Biological Markers; 0/Dietary Proteins; 0/Fatty Acids, Omega-3; 0/Phospholipids; 0/Placebos; 1553-41-9/Eicosapentaenoic Acid

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