| Oral L-carnitine combined with training promotes changes in skeletal muscle. | |
| | |
MedLine Citation:
|
PMID: 12405699 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this study was to determine whether oral L-carnitine supplementation enhances the responses of skeletal muscle to training in seven 2-year-old Standardbreds. Four horses were supplemented with 10 g/day L-carnitine for 10 weeks and 3 horses served as controls. All horses were exercised regularly every second day on a treadmill for 5 weeks (training period) and housed in individual boxes for 5 additional weeks (detraining period). The training period consisted of 8 high- and 8 low-speed exercises carried out in alternating sequence. Gluteus medius muscle biopsies were taken at Weeks 0 (pretraining), 5 (post-training) and 10 (detraining). Muscular adaptations to training were observed mainly in the L-carnitine-supplemented horses and included an increase in the percentage of type IIA fibres (delta35%, P<0.05), atrophy of type I fibres (delta24%, P<0.01), a rise in the capillary-to-fibre ratio (delta40%, P<0.01) and an increase in the quantitative reaction of periodic acid Schiff stain (delta11%, P<0.05), used as an indicator of intrafibre glycogen content. After detraining, most of these adaptations reverted towards the pretraining situation. Therefore, exogenous carnitine has an additive effect on muscular responses to training and this should be favourable to improve athletic performance. Nevertheless, further studies are necessary to show whether muscle carnitine content is a limiting factor for fatty acid oxidation. |
| | |
Authors:
|
J L L Rivero; H P Sporleder; E Quiroz-Rothe; I Vervuert; M Coenen; J Harmeyer |
Related Documents
:
|
11817549 - Clinical and endoscopic evidence of progression in 152 cases of equine recurrent laryng... 15038439 - The influence of repeated arthrocentesis and exercise on matrix metalloproteinase and t... 16685549 - Hyperhydration prior to a simulated second day of the 3-day moderate intensity equestri... 11230769 - Clinical experiences with axial deviation of the aryepiglottic folds in 52 racehorses. 21656229 - No case of exercise-associated hyponatraemia in top male ultra-endurance cyclists: the ... 10622169 - Epidemiologic analysis of factors influencing exertional rhabdomyolysis in thoroughbreds. 23667629 - Acute exercise induces fgf21 expression in mice and in healthy humans. 1112949 - Effect of beta adrenergic blockage on bronchial sensitivity to inhaled acetylcholine in... 10776889 - Cardiorespiratory and metabolic responses to exercise in hbsc sickle cell patients. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Equine veterinary journal. Supplement Volume: - ISSN: - ISO Abbreviation: Equine Vet J Suppl Publication Date: 2002 Sep |
Date Detail:
|
Created Date: 2002-10-30 Completed Date: 2003-02-26 Revised Date: 2007-05-18 |
Medline Journal Info:
|
Nlm Unique ID: 9614088 Medline TA: Equine Vet J Suppl Country: England |
Other Details:
|
Languages: eng Pagination: 269-74 Citation Subset: IM |
Affiliation:
|
Department of Anatomy, University of Cordoba, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological Administration, Oral Animals Biopsy / veterinary Capillaries Carnitine / administration & dosage*, pharmacology Electrophoresis, Polyacrylamide Gel / veterinary Exercise Test / veterinary Female Glycogen / metabolism Histocytochemistry / veterinary Horses / physiology* Immunohistochemistry / veterinary Male Muscle Fibers, Fast-Twitch / drug effects* Muscle Fibers, Slow-Twitch / drug effects* Muscle, Skeletal / anatomy & histology, chemistry, drug effects* Myosin Heavy Chains / metabolism Physical Conditioning, Animal / physiology* Random Allocation |
| Chemical | |
Reg. No./Substance:
|
0/Myosin Heavy Chains; 541-15-1/Carnitine; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exercise-induced tendon hypertrophy: cross-sectional area changes during growth are influenced by ex...
Next Document: Training-induced apoptosis in skeletal muscle.