Document Detail

Oral L-arginine supplementation and faecal calprotectin levels in very low birth weight neonates.
MedLine Citation:
PMID:  22555780     Owner:  NLM     Status:  Publisher    
Objective:The objective of this study is to determine the potential effect of oral L-arginine supplementation on intestinal inflammation in very low birth weight (VLBW) neonates, as estimated by faecal calprotectin levels.Study Design:The study enrolled 83 VLBW neonates with birth weight 1500 g and gestational age 34 weeks. In this double-blind study, 40 neonates received daily oral L-arginine supplementation of 1.5 mmol kg(-1) per day between the 3rd and 28th day of life, and 43 neonates placebo. Stool samples were collected on days 3, 14 and 28, and calprotectin was measured by enzyme-linked immunosorbent assay.Result:Calprotectin values significantly decreased over time in both groups (P=0.032). No difference in faecal calprotectin values was recorded between neonates receiving arginine supplementation and neonates receiving placebo at days 3, 14 and 28.Conclusion:Faecal calprotectin values decrease with increasing postnatal age in VLBW infants, but this is not related to arginine supplementation.Journal of Perinatology advance online publication, 3 May 2012; doi:10.1038/jp.2012.51.
E Polycarpou; S Zachaki; V Papaevangelou; M Tsolia; A Kyriacou; C Kostalos; D Kafetzis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-03
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  -     ISSN:  1476-5543     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Neonatal Intensive Care Unit, 'Alexandra' Hospital, Athens, Greece.
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