| Oral L-arginine supplementation and faecal calprotectin levels in very low birth weight neonates. | |
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MedLine Citation:
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PMID: 22555780 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective:The objective of this study is to determine the potential effect of oral L-arginine supplementation on intestinal inflammation in very low birth weight (VLBW) neonates, as estimated by faecal calprotectin levels.Study Design:The study enrolled 83 VLBW neonates with birth weight 1500 g and gestational age 34 weeks. In this double-blind study, 40 neonates received daily oral L-arginine supplementation of 1.5 mmol kg(-1) per day between the 3rd and 28th day of life, and 43 neonates placebo. Stool samples were collected on days 3, 14 and 28, and calprotectin was measured by enzyme-linked immunosorbent assay.Result:Calprotectin values significantly decreased over time in both groups (P=0.032). No difference in faecal calprotectin values was recorded between neonates receiving arginine supplementation and neonates receiving placebo at days 3, 14 and 28.Conclusion:Faecal calprotectin values decrease with increasing postnatal age in VLBW infants, but this is not related to arginine supplementation.Journal of Perinatology advance online publication, 3 May 2012; doi:10.1038/jp.2012.51. |
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Authors:
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E Polycarpou; S Zachaki; V Papaevangelou; M Tsolia; A Kyriacou; C Kostalos; D Kafetzis |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-03 |
Journal Detail:
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Title: Journal of perinatology : official journal of the California Perinatal Association Volume: - ISSN: 1476-5543 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8501884 Medline TA: J Perinatol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Neonatal Intensive Care Unit, 'Alexandra' Hospital, Athens, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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