Document Detail


Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy.
MedLine Citation:
PMID:  22244236     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the most promising therapies for food allergy is oral immunotherapy (OIT), in which small amounts of allergen are administered in increasing amounts, with the immediate goal of desensitization and the long-term goal of tolerance. However, safety and standardization concerns prevent its widespread use, and a subgroup of patients may experience severe allergic reactions. These concerns might be addressed by another promising therapy involving anti-IgE monoclonal antibodies (mAb), which can reduce allergic reactions associated with food administration. A recent pilot study combining anti-IgE mAb with OIT suggests that anti-IgE mAb might improve the safety, rapidity, and efficacy of OIT.
Authors:
Kari C Nadeau; Arunima Kohli; Shuba Iyengar; Rosemarie H DeKruyff; Dale T Umetsu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunology and allergy clinics of North America     Volume:  32     ISSN:  1557-8607     ISO Abbreviation:  Immunol Allergy Clin North Am     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-06-28     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  8805635     Medline TA:  Immunol Allergy Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Stanford Food Allergy Program, Division of Immunology and Allergy, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Allergic Agents / therapeutic use
Antibodies, Anti-Idiotypic / therapeutic use*
Antibodies, Monoclonal / therapeutic use
Antibodies, Monoclonal, Humanized / therapeutic use
Child
Child, Preschool
Desensitization, Immunologic / methods*
Food / adverse effects
Food Hypersensitivity / immunology,  therapy*
Humans
Immune Tolerance
Immunotherapy / methods*
Infant
Middle Aged
Young Adult
Chemical
Reg. No./Substance:
0/Anti-Allergic Agents; 0/Antibodies, Anti-Idiotypic; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/anti-IgE antibodies; 0/omalizumab; 0/talizumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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