| Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy. | |
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MedLine Citation:
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PMID: 22244236 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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One of the most promising therapies for food allergy is oral immunotherapy (OIT), in which small amounts of allergen are administered in increasing amounts, with the immediate goal of desensitization and the long-term goal of tolerance. However, safety and standardization concerns prevent its widespread use, and a subgroup of patients may experience severe allergic reactions. These concerns might be addressed by another promising therapy involving anti-IgE monoclonal antibodies (mAb), which can reduce allergic reactions associated with food administration. A recent pilot study combining anti-IgE mAb with OIT suggests that anti-IgE mAb might improve the safety, rapidity, and efficacy of OIT. |
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Authors:
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Kari C Nadeau; Arunima Kohli; Shuba Iyengar; Rosemarie H DeKruyff; Dale T Umetsu |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Immunology and allergy clinics of North America Volume: 32 ISSN: 1557-8607 ISO Abbreviation: Immunol Allergy Clin North Am Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-16 Completed Date: 2012-06-28 Revised Date: 2013-01-18 |
Medline Journal Info:
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Nlm Unique ID: 8805635 Medline TA: Immunol Allergy Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 111-33 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Stanford Food Allergy Program, Division of Immunology and Allergy, Stanford University, 300 Pasteur Drive, Stanford, CA 94305, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anti-Allergic Agents / therapeutic use Antibodies, Anti-Idiotypic / therapeutic use* Antibodies, Monoclonal / therapeutic use Antibodies, Monoclonal, Humanized / therapeutic use Child Child, Preschool Desensitization, Immunologic / methods* Food / adverse effects Food Hypersensitivity / immunology, therapy* Humans Immune Tolerance Immunotherapy / methods* Infant Middle Aged Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anti-Allergic Agents; 0/Antibodies, Anti-Idiotypic; 0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/anti-IgE antibodies; 0/omalizumab; 0/talizumab |
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