| Oral IGF-I enhances nutrient and electrolyte absorption in neonatal piglet intestine. | |
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MedLine Citation:
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PMID: 10484387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of orally administered insulin-like growth factor-I (IGF-I) on small intestinal structure and function was studied in 5-day-old colostrum-deprived piglets. Human recombinant IGF-I (3.5 mg. kg(-1). day(-1)) or control vehicle was given orogastrically for 4 days. Body weights, jejunal and ileal mucosa wet and dry weights, and serum IGF-I levels were similar in the two groups. Small intestinal villus height and crypt depth and jejunal enterocyte microvillar dimensions were also similar between groups. Oral IGF-I produced higher rates of jejunal ion transport because of increased basal Na+ absorption. Short-circuit current responses to mucosal addition of D-glucose and L-alanine and net transepithelial absorption of 3-O-methylglucose were increased by IGF-I. Carrier-mediated uptake of D-glucose per milligram in everted jejunal sleeves was greater in IGF-I-treated piglets because of a significantly greater maximal rate of uptake. We conclude that rates of net Na+ and Na+-dependent nutrient absorption are enhanced in piglets treated with oral IGF-I, and this effect is independent of changes in mucosal mass or surface area. |
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Authors:
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A N Alexander; H V Carey |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 277 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-28 Completed Date: 1999-10-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G619-25 Citation Subset: IM |
Affiliation:
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Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animal Nutritional Physiological Phenomena* Animals Animals, Newborn / anatomy & histology, blood Body Weight Electrolytes / metabolism* Humans Ileum / metabolism Insulin-Like Growth Factor I / analysis, pharmacology* Intestinal Absorption / drug effects* Intestinal Mucosa / anatomy & histology Ion Transport Jejunum / metabolism Microvilli / ultrastructure Recombinant Proteins Swine |
| Grant Support | |
ID/Acronym/Agency:
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F32-DK-09629/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Electrolytes; 0/Recombinant Proteins; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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