Document Detail


Oral food desensitization.
MedLine Citation:
PMID:  20730515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immunologic interactions in the gastrointestinal tract are extensive and complex. In most cases, the end result of this activity is one of tolerance, which refers to the inhibition of an immune response. However, in a minority of cases, food allergy develops, and this seems to be increasing in prevalence. We continue to learn about the mechanisms involved in these processes and the factors that may promote tolerance as opposed to allergy. At this point, management of food allergy consists of allergen avoidance and readiness to manage an accidental exposure reaction, but using current knowledge of gastrointestinal immunity, researchers are investigating immunomodulatory approaches that will provide "active" therapy for food allergy and induce tolerance. Oral immunotherapy is one important therapy being studied, and in this article, we review recent results from studies of this potential treatment for food allergy.
Authors:
Todd D Green; A Wesley Burks
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current allergy and asthma reports     Volume:  10     ISSN:  1534-6315     ISO Abbreviation:  Curr Allergy Asthma Rep     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101096440     Medline TA:  Curr Allergy Asthma Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  IM    
Affiliation:
Children's Hospital of Pittsburgh of UPMC, PA 15224, USA. todd.green@chp.edu
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MeSH Terms
Descriptor/Qualifier:
Desensitization, Immunologic / methods*
Food Hypersensitivity / immunology,  therapy*
Humans
Immune Tolerance*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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