| Oral food desensitization. | |
MedLine Citation:
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PMID: 20730515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunologic interactions in the gastrointestinal tract are extensive and complex. In most cases, the end result of this activity is one of tolerance, which refers to the inhibition of an immune response. However, in a minority of cases, food allergy develops, and this seems to be increasing in prevalence. We continue to learn about the mechanisms involved in these processes and the factors that may promote tolerance as opposed to allergy. At this point, management of food allergy consists of allergen avoidance and readiness to manage an accidental exposure reaction, but using current knowledge of gastrointestinal immunity, researchers are investigating immunomodulatory approaches that will provide "active" therapy for food allergy and induce tolerance. Oral immunotherapy is one important therapy being studied, and in this article, we review recent results from studies of this potential treatment for food allergy. |
Authors:
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Todd D Green; A Wesley Burks |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current allergy and asthma reports Volume: 10 ISSN: 1534-6315 ISO Abbreviation: Curr Allergy Asthma Rep Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101096440 Medline TA: Curr Allergy Asthma Rep Country: United States |
Other Details:
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Languages: eng Pagination: 391-7 Citation Subset: IM |
Affiliation:
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Children's Hospital of Pittsburgh of UPMC, PA 15224, USA. todd.green@chp.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Desensitization, Immunologic
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methods* Food Hypersensitivity / immunology, therapy* Humans Immune Tolerance* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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