| Oral Factor Xa and Direct Thrombin Inhibitors: A Clinical Perspective. | |
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MedLine Citation:
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PMID: 22269826 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Oral anticoagulation used to be synonymous with warfarin until the recent approval of oral direct thrombin inhibitors and factor Xa inhibitors in United States and other countries across the world. Thrombosis prevention and treatment continue to be the main objective and goal for surgical and medical patients. Regulatory agencies continue to revise their guidelines to treat these patients with appropriate medication and for optimal duration. As the choices for oral anticoagulants increase, with many oral anticoagulant drugs currently in the pipeline awaiting completion of clinical trials, the guidelines for venous thromboembolism prevention, stroke prevention in atrial fibrillation, and treatment of acute arterial and venous thrombi will also shift from the current standards to new standards set by these clinical trials for optimal dosing and duration of treatment. However, it must be reinforced that these new oral anticoagulants are distinct pharmacological compounds with specific targets and will also have distinct clinical indications for use. |
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Authors:
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Indermohan Thethi; Bruce Lewis; Jawed Fareed |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-20 |
Journal Detail:
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Title: Journal of burn care & research : official publication of the American Burn Association Volume: - ISSN: 1559-0488 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262774 Medline TA: J Burn Care Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Department of Medicine, Aurora Memorial Hospital, Burlington, Wisconsin; and Departments of †Medicine and ‡Pathology and Pharmacology, Loyola University Chicago, Maywood, Illinois. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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