Document Detail

Oral Creatine Supplementation Augments the Repeated Bout Effect.
MedLine Citation:
PMID:  23349298     Owner:  NLM     Status:  Publisher    
PURPOSE: We examined the effects of creatine supplementation on the response to repeated bouts of resistance exercise. METHODS: Young men (24.1 ± 5.2 yr) were divided into Creatine (CM, n = 9) and Placebo (PL, n = 9) groups. On day (D) 1 and D15, subjects performed four sets of bicep curls at 75% 1-RM to concentric failure. On D8-D13, subjects consumed either 20g/d creatine monohydrate or placebo. Muscle soreness and elbow joint range of motion (ROM) were assessed on D1-D5 and D15-D19. Serum creatine kinase activity (CK) was assessed on D1, D3, D5, D15, D17, and D19. RESULTS: The first exercise bout produced increases in muscle soreness and CK, and decreases in ROM in both groups (p < 0.001). The second bout produced lesser rises in serum CK, muscle soreness, and a lesser decrease in ROM (bout effect, p < 0.01 for all), with greater attenuation of these damage markers in CM than PL. CK levels on D17 were lower (+110% over D15 for CM vs. +343% for PL), muscle soreness from D15-19 was lower (-75% for CM vs. -56% for PL compared to first bout), and elbow ROM was decreased in PL, but not CM on D16 (p < 0.05 for all). CONCLUSIONS: Creatine supplementation provides an additive effect on blunting the rise of muscle damage markers following a repeated bout of resistance exercise. The mechanism by which creatine augments the repeated bout effect is unknown, but is likely due to a combination of creatine's multifaceted functions.
F T Veggi K; Marco Machado; Alexander J Koch; Sandro C Santana; Sedison S Oliveira; Michael J Stec
Related Documents :
9804498 - Exercise and extracorporeal blood cooling during hemodialysis.
17579278 - Effect of cooling on the rectal tone.
10024848 - Multi-loop control of liquid cooling garment systems.
19084988 - Evaluation of exercised or cooled skeletal muscle on the basis of diffusion-weighted ma...
22828668 - Exaggerated blood pressure response to exercise in athletes: dysmetabolism or altered a...
8705758 - Ammonia response to exercise in patients with congestive heart failure.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  -     ISSN:  1543-2742     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Laboratory of Physiology and Biokinetic, Faculty of Biological Sciences and Health, UNIG Campus V at Itaperuna, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Circulating angiopoietins and cardiovascular mortality in cardiogenic shock.
Next Document:  Cord blood-derived CD34+ hematopoietic cells with low levels of mitochondrial mass are enriched in h...