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Oral Creatine Supplementation Augments the Repeated Bout Effect.
MedLine Citation:
PMID:  23349298     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE: We examined the effects of creatine supplementation on the response to repeated bouts of resistance exercise. METHODS: Young men (24.1 ± 5.2 yr) were divided into Creatine (CM, n = 9) and Placebo (PL, n = 9) groups. On day (D) 1 and D15, subjects performed four sets of bicep curls at 75% 1-RM to concentric failure. On D8-D13, subjects consumed either 20g/d creatine monohydrate or placebo. Muscle soreness and elbow joint range of motion (ROM) were assessed on D1-D5 and D15-D19. Serum creatine kinase activity (CK) was assessed on D1, D3, D5, D15, D17, and D19. RESULTS: The first exercise bout produced increases in muscle soreness and CK, and decreases in ROM in both groups (p < 0.001). The second bout produced lesser rises in serum CK, muscle soreness, and a lesser decrease in ROM (bout effect, p < 0.01 for all), with greater attenuation of these damage markers in CM than PL. CK levels on D17 were lower (+110% over D15 for CM vs. +343% for PL), muscle soreness from D15-19 was lower (-75% for CM vs. -56% for PL compared to first bout), and elbow ROM was decreased in PL, but not CM on D16 (p < 0.05 for all). CONCLUSIONS: Creatine supplementation provides an additive effect on blunting the rise of muscle damage markers following a repeated bout of resistance exercise. The mechanism by which creatine augments the repeated bout effect is unknown, but is likely due to a combination of creatine's multifaceted functions.
Authors:
F T Veggi K; Marco Machado; Alexander J Koch; Sandro C Santana; Sedison S Oliveira; Michael J Stec
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  -     ISSN:  1543-2742     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laboratory of Physiology and Biokinetic, Faculty of Biological Sciences and Health, UNIG Campus V at Itaperuna, Brazil.
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