| Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 19566844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. L-histidine is generally found in meat, poultry and fish. To investigate its effects on blood pressure, L-histidine was administered to 9-week-old spontaneously hypertensive rats (SHR). 2. Oral administration of L-histidine (100 mg / kg) increased histamine content in cerebrospinal fluid and reduced mean arterial pressure (MAP) in SHR. Intracerebroventricular injection of L-histidine (0.01 microg / 5 microL) also caused a decrease in MAP, which was reversed by cotreatment with the histamine H3 receptor antagonist thioperamide (20.4 microg / 5 microL, i.c.v.). There was a significant, time-dependent increase (over 6 h) in the NOx (NO2- + NO3-) content of the dialysate from the rostral ventrolateral medulla (RVLM), a major vasomotor centre, after oral administration of L-histidine. 3. In another experiment, SHR were treated with l-histidine (100 mg / kg) twice a day for 4 weeks. Chronic treatment with L-histidine inhibited the age-dependent increases in systolic blood pressure and urinary noradrenaline excretion seen in vehicle-treated SHR. Conversely, intracerebroventricular injection of thioperamide (20.4 microg / 5 microL, i.c.v.) reversed the decrease in MAP in response to L-histidine in SHR. 4. Reverse transcription-polymerase chain reaction analysis revealed that the aortic expression of angiotensin-converting enzyme mRNA was suppressed by chronic treatment with L-histidine. 5. These results suggest that L-histidine decreases blood pressure by attenuating sympathetic output via the central histamine H3 receptor in SHR. In addition, the antihypertensive effects of L-histidine appear to be associated with an increase in nitric oxide in the RVLM. |
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Authors:
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Hiroe Toba; Ayako Nakamori; Yoshimi Tanaka; Ryosuke Yukiya; Keisuke Tatsuoka; Masako Narutaki; Masaaki Tokitaka; Hitoshi Hariu; Miyuki Kobara; Tetsuo Nakata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 37 ISSN: 1440-1681 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-06-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 62-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan. toba@mb.kyoto-phu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Antihypertensive Agents / administration & dosage, pharmacology* Aorta / drug effects, metabolism Blood Pressure / drug effects Histamine / cerebrospinal fluid Histamine Agonists / pharmacology Histamine Antagonists / pharmacology Histidine / administration & dosage, pharmacology* Injections, Intraventricular Male Medulla Oblongata / drug effects*, metabolism Nitric Oxide / metabolism* Norepinephrine / urine Peptidyl-Dipeptidase A / metabolism Piperidines / administration & dosage, pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Receptors, Histamine H3 / drug effects* Vasomotor System / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Histamine Agonists; 0/Histamine Antagonists; 0/Piperidines; 0/Receptors, Histamine H3; 10102-43-9/Nitric Oxide; 106243-16-7/thioperamide; 51-41-2/Norepinephrine; 51-45-6/Histamine; 71-00-1/Histidine; EC 3.4.15.1/Peptidyl-Dipeptidase A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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