Document Detail


Oral L-histidine exerts antihypertensive effects via central histamine H3 receptors and decreases nitric oxide content in the rostral ventrolateral medulla in spontaneously hypertensive rats.
MedLine Citation:
PMID:  19566844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. L-histidine is generally found in meat, poultry and fish. To investigate its effects on blood pressure, L-histidine was administered to 9-week-old spontaneously hypertensive rats (SHR). 2. Oral administration of L-histidine (100 mg / kg) increased histamine content in cerebrospinal fluid and reduced mean arterial pressure (MAP) in SHR. Intracerebroventricular injection of L-histidine (0.01 microg / 5 microL) also caused a decrease in MAP, which was reversed by cotreatment with the histamine H3 receptor antagonist thioperamide (20.4 microg / 5 microL, i.c.v.). There was a significant, time-dependent increase (over 6 h) in the NOx (NO2- + NO3-) content of the dialysate from the rostral ventrolateral medulla (RVLM), a major vasomotor centre, after oral administration of L-histidine. 3. In another experiment, SHR were treated with l-histidine (100 mg / kg) twice a day for 4 weeks. Chronic treatment with L-histidine inhibited the age-dependent increases in systolic blood pressure and urinary noradrenaline excretion seen in vehicle-treated SHR. Conversely, intracerebroventricular injection of thioperamide (20.4 microg / 5 microL, i.c.v.) reversed the decrease in MAP in response to L-histidine in SHR. 4. Reverse transcription-polymerase chain reaction analysis revealed that the aortic expression of angiotensin-converting enzyme mRNA was suppressed by chronic treatment with L-histidine. 5. These results suggest that L-histidine decreases blood pressure by attenuating sympathetic output via the central histamine H3 receptor in SHR. In addition, the antihypertensive effects of L-histidine appear to be associated with an increase in nitric oxide in the RVLM.
Authors:
Hiroe Toba; Ayako Nakamori; Yoshimi Tanaka; Ryosuke Yukiya; Keisuke Tatsuoka; Masako Narutaki; Masaaki Tokitaka; Hitoshi Hariu; Miyuki Kobara; Tetsuo Nakata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  37     ISSN:  1440-1681     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Affiliation:
Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan. toba@mb.kyoto-phu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Antihypertensive Agents / administration & dosage,  pharmacology*
Aorta / drug effects,  metabolism
Blood Pressure / drug effects
Histamine / cerebrospinal fluid
Histamine Agonists / pharmacology
Histamine Antagonists / pharmacology
Histidine / administration & dosage,  pharmacology*
Injections, Intraventricular
Male
Medulla Oblongata / drug effects*,  metabolism
Nitric Oxide / metabolism*
Norepinephrine / urine
Peptidyl-Dipeptidase A / metabolism
Piperidines / administration & dosage,  pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Receptors, Histamine H3 / drug effects*
Vasomotor System / drug effects
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Histamine Agonists; 0/Histamine Antagonists; 0/Piperidines; 0/Receptors, Histamine H3; 10102-43-9/Nitric Oxide; 106243-16-7/thioperamide; 51-41-2/Norepinephrine; 51-45-6/Histamine; 71-00-1/Histidine; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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