Document Detail

Oral Administration of Bacillus subtilis Strain BSB3 Can Prevent Heat Stress-Related Adverse Effects in Rats.
MedLine Citation:
PMID:  25052088     Owner:  NLM     Status:  Publisher    
AIMS: To determine the efficacy of Bacillus subtilis strain in prevention of heat stress related complications in rats.
METHODS AND RESULTS: Male Sprague-Dawley rats weighing 250-300 g were treated by oral gavage with B. subtilis BSB3 strain or PBS twice a day for two days. Half of the rats of each group were exposed to heat stress (45(o) C, relative humidity 55% for 25 min) while the remaining rats were placed at identical conditions but at 25°C. Bacterial translocation, histological changes in the intestine, cytokines profile, serum lipopolysaccharide level (LPS), as well as vesiculation of erythrocytes were analyzed and compared between groups. Adverse effects of heat stress (morphological changes in intestine, bacterial translocation, elevated levels of LPS and IL-10, increased vesiculation of erythrocytes) were observed only in rats not protected with B. subtilis strain and exposed to heat. All registered parameters in rats pretreated with bacilli and exposed to heat were similar to control groups.
CONCLUSIONS: B. subtilis BS3B strain was effective in the prevention of complications related to heat stress in rats.
SIGNIFICANCE AND IMPACT OF STUDY: This work will contribute towards better understanding of probiotics' mechanisms of action and will bring new approaches to characterize and use of beneficial bacteria. This article is protected by copyright. All rights reserved.
Timothy Moore; Ludmila Globa; Oleg Pustovyy; Vitaly Vodyanoy; Iryna Sorokulova
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-23
Journal Detail:
Title:  Journal of applied microbiology     Volume:  -     ISSN:  1365-2672     ISO Abbreviation:  J. Appl. Microbiol.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706280     Medline TA:  J Appl Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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