| Oral (99m)Tc-DTPA simultaneous determination of duodenobiliary reflux and intestinal permeability in patients after choledocholithotomy plus T-tube drainage. | |
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MedLine Citation:
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PMID: 16286270 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The high choledocholithiasis recurrence rate after choledocholithotomy plus T-tube drainage is related to biliary bacterial infection. These bacteria are from the intestine, either via the major duodenal papilla, or the penetrating intestinal mucosa. It is therefore possible that duodenobiliary reflux and increased intestinal permeability exist in patients who have undergone choledocholithotomy. This study was undertaken to find the evidence of duodenobiliary reflux and to assess intestinal permeability in these patients. METHODS: Twenty-one patients who underwent choledocholithotomy plus T-tube drainage 2 months ago, and 11 healthy volunteers (controls) took orally 185MBq of (99m)Tc-DTPA. The patients' bile was collected in the next 2 hours via a T-tube and the (99m)Tc-DTPA radioactivity in the bile was counted. Intestinal permeability was evaluated by measuring the 24-hour urinary excretion rate of ingested (99m)Tc-DTPA in both patients and controls. RESULTS: In 6 of the 21 patients, radioactivity in the bile was detected. The intestinal permeability was significantly higher in patients (11.45%+/-6.16%) than that in controls (3.61%+/-1.63%, t=3.28, P<0.05). CONCLUSIONS: Duodenobiliary reflux exists in patients who have undergone choledocholithotomy plus T-tube drainage. The intestinal permeability is higher in these patients than in healthy subjects. Duodenobiliary reflux and increased intestinal permeability may be factors of cholelithiasis recurrence. |
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Authors:
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Shao-Long Sun; Shuo-Dong Wu; Xiao-Bo Zhang |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Hepatobiliary & pancreatic diseases international : HBPD INT Volume: 4 ISSN: 1499-3872 ISO Abbreviation: HBPD INT Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-11-15 Completed Date: 2006-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101151457 Medline TA: Hepatobiliary Pancreat Dis Int Country: China |
Other Details:
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Languages: eng Pagination: 593-6 Citation Subset: IM |
Affiliation:
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Department of General Surgery, Institute of Clinical Medicine, Second Affiliated Hospital, China Medical University, Shenyang 110004, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Choledochostomy / methods* Drainage Female Humans Intestinal Absorption / physiology* Intestinal Mucosa / metabolism Male Middle Aged Radiopharmaceuticals / administration & dosage, diagnostic use, pharmacokinetics, urine Reference Values Technetium Tc 99m Pentetate / administration & dosage, diagnostic use*, pharmacokinetics*, urine |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 65454-61-7/Technetium Tc 99m Pentetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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