Document Detail

Oral 13-cis-retinoic acid therapy in adenoma sebaceum symmetricum and the most severe forms of acne and rosacea
MedLine Citation:
PMID:  6223455     Owner:  NLM     Status:  MEDLINE    
Twenty-one patients with severe acne (acne papulopustulosa, acne conglobata, acne cystica), six patients with severe rosacea (rosacea paulopustulosa, rosacea conglobata, rhinophyma), and three patients with tuberous sclerosis were treated with 13-cis-retinoic acid for 6-48 weeks. Most patients had been previously treated with dermabrasion, antibiotics or metronidazole. Dependent on the severeness of the pathological symptoms 13-cis-retinoic acid was administered at a dose of 0.2 to 0.5 mg/kg body weight and was then reduced every 4 weeks. We confirm the sebostatic and antiinflammatory effect of the 13-cis-retinoic acid and long-lasting remissions. Side effects had not been serious.
E Vogt; H C Friederich
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Zeitschrift für Hautkrankheiten     Volume:  58     ISSN:  0301-0481     ISO Abbreviation:  Z. Hautkr.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-08-11     Completed Date:  1983-08-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367576     Medline TA:  Z Hautkr     Country:  GERMANY, WEST    
Other Details:
Languages:  ger     Pagination:  646-67     Citation Subset:  IM    
Vernacular Title:
Orale 13-cis-Retinsäure-Therapie bei Adenoma sebaceum symmetricum und schwersten Akne- und Rosazeaformen.
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MeSH Terms
Acne Vulgaris / drug therapy*
Adenoma / drug therapy*
Administration, Oral
Middle Aged
Rosacea / drug therapy*
Sebaceous Gland Neoplasms / drug therapy*
Tretinoin / adverse effects,  therapeutic use*
Reg. No./Substance:
302-79-4/Tretinoin; 4759-48-2/Isotretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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