Document Detail

Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury.
MedLine Citation:
PMID:  16220574     Owner:  NLM     Status:  MEDLINE    
The protective effects of the juice of Opuntia ficus indica fruit (prickly pear) against carbon tetrachloride (CCl(4))-induced hepatotoxicity were examined in rats. The animals were treated orally with the juice (3 mL/rat) 2 h after administration of the hepatotoxic agent. Preventive effects were studied by giving the juice (3 mL/rat) for 9 consecutive days. On day 9 the rats received the hepatotoxic agent. Morphological and biochemical evaluations were carried out 24, 48 and 72 h after induction of the hepatic damage. Data show that O. ficus indica fruit juice administration exerts protective and curative effects against the CCl(4)-induced degenerative process in rat liver. Histology evaluation revealed a normal hepatic parenchyma at 48 h; the injury was fully restored after 72 h. Moreover, a significant reduction in CCl(4)-induced increase of GOT and GPT plasma levels is evident; these data are in agreement with the functional improvement of hepatocytes. O. ficus indica fruit juice contains many phenol compounds, ascorbic acid, betalains, betacyanins, and a flavonoid fraction, which consists mainly of rutin and isorhamnetin derivatives. Hepatoprotection may be related to the flavonoid fraction of the juice, but other compounds, such as vitamin C and betalains could, synergistically, counteract many degenerative processes by means of their antioxidant activity.
E M Galati; M R Mondello; E R Lauriano; M F Taviano; M Galluzzo; N Miceli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  19     ISSN:  0951-418X     ISO Abbreviation:  Phytother Res     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-18     Completed Date:  2006-01-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  796-800     Citation Subset:  IM    
Copyright Information:
Copyright 2005 John Wiley & Sons, Ltd.
Pharmaco-Biological Department, School of Pharmacy, University of Messina, Vill. SS. Annunziata, Italy.
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MeSH Terms
Carbon Tetrachloride / diagnostic use
Drug-Induced Liver Injury / blood,  etiology,  pathology,  prevention & control
Liver / drug effects,  enzymology
Protective Agents / administration & dosage,  pharmacology*,  therapeutic use
Rats, Wistar
Reg. No./Substance:
0/Protective Agents; 56-23-5/Carbon Tetrachloride

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