Document Detail


Optogenetic strategies to dissect the neural circuits that underlie reward and addiction.
MedLine Citation:
PMID:  23043156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Optogenetic strategies for perturbation of neural circuit function have begun to revolutionize systems neuroscience. Whereas optogenetics has proven to be a powerful approach for studying neural systems, the tools to conduct these experiments are still continuously evolving. Here we briefly summarize available hardware and reagents that can be used for studying behaviors related to reward and addiction. In addition, we discuss recent studies in which these strategies have been applied to study neural circuit function in brain slices as well as awake and behaving animals. Collectively, this work serves as a brief introduction to optogenetic techniques and highlights how these tools can be applied to elucidate the neural circuits that underlie reward processing and addiction.
Authors:
Alice M Stamatakis; Garret D Stuber
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in medicine     Volume:  2     ISSN:  2157-1422     ISO Abbreviation:  Cold Spring Harb Perspect Med     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-05     Completed Date:  2013-05-06     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  101571139     Medline TA:  Cold Spring Harb Perspect Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Behavior, Addictive / physiopathology*
Electrophysiology / methods*
Humans
Neurons / physiology*
Opsins / metabolism
Photic Stimulation
Reward*
Synaptic Transmission*
Ventral Tegmental Area / physiology*
Grant Support
ID/Acronym/Agency:
DA029325/DA/NIDA NIH HHS; DA032750/DA/NIDA NIH HHS; F31 DA034472/DA/NIDA NIH HHS; T32 NS007431-13/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Opsins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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