Document Detail


Optofluidic integrated cell sorter fabricated by femtosecond lasers.
MedLine Citation:
PMID:  22868483     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The main trend in optofluidics is currently towards full integration of the devices, thus improving automation, compactness and portability. In this respect femtosecond laser microfabrication is a very powerful technology given its capability of producing both optical waveguides and microfluidic channels. The current challenge in biology is the possibility to perform bioassays at the single cell level to unravel the hidden complexity in nominally homogeneous populations. Here we report on a new device implementing a fully integrated fluorescence-activated cell sorter. This non-invasive device is specifically designed to operate with a limited amount of cells but with a very high selectivity in the sorting process. Characterization of the device with beads and validation with human cells are presented.
Authors:
F Bragheri; P Minzioni; R Martinez Vazquez; N Bellini; P Paiè; C Mondello; R Ramponi; I Cristiani; R Osellame
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-7
Journal Detail:
Title:  Lab on a chip     Volume:  -     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Istituto di Fotonica e Nanotecnologie (IFN) - CNR, Dipartimento di Fisica - Politecnico di Milano, P.zza Leonardo da Vinci 32, 20133 Milano, Italy. roberto.osellame@ifn.cnr.it.
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