Document Detail

An Optofluidic SERS Microsystem for Sensitive and Repeatable On-Site Detection of Chemical Contaminants.
MedLine Citation:
PMID:  22924879     Owner:  NLM     Status:  Publisher    
We demonstrate highly sensitive detection of real-world food and water contaminants using a portable and automated optofluidic SERS microsystem. The optofluidic SERS device utilizes a porous microfluidic matrix formed by packed silica microspheres to concentrate silver nanoparticles and adsorbed analyte molecules, resulting in greatly improved SERS detection performance. In addition, a passive micromixer that mixes silver nanoparticles into the sample solution is integrated into the device for improved automation. Furthermore, two optical fibers are integrated into the device and aligned to the detection volume to improve the automation as compared to confocal SERS, which requires focusing and alignment. The device exhibits up to two orders of magnitude improvement in SERS performance as compared to conventional microfluidic SERS in an open channel. Using the optofluidic SERS device, the food contaminant melamine was detected in concentrations as low as 125 ppb, while the fungicide thiram was detected in concentrations as low as 1 ppb. In both cases, the reported results meet the U. S. federal requirements. The combination of this optofluidic SERS microsystem with state of the art portable spectrometers will lead to highly sensitive, portable, and automated sensing systems for on-site detection of food and water contaminants.
Soroush H Yazdi; Ian M White
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-27
Journal Detail:
Title:  Analytical chemistry     Volume:  -     ISSN:  1520-6882     ISO Abbreviation:  Anal. Chem.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370536     Medline TA:  Anal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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