Document Detail


Optison (FS069) disrupts the blood-brain barrier in rats.
MedLine Citation:
PMID:  11004029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Optison is a new echocardiographic contrast agent, designed for IV injection, that is very useful in delineating cardiac structures during ultrasound examination. Because Optison could be a valuable adjunct in the diagnosis and evaluation of congenital heart disease, this study was undertaken to assess its effects on the blood-brain barrier when introduced directly in the cerebral circulation, as might occur with some congenital lesions. In this study, Sprague-Dawley rats were anesthetized, and Optison, at various dosages, was injected into the carotid artery. After this, Evans blue dye, a marker for blood-brain barrier disruption, was injected at different time intervals. Gross and histologic examination of the animals' brains revealed disruption of the blood-brain barrier that appeared to be Optison-dosage-dependent. Although the mechanism for this disruption is unclear, it may be related to the use of octofluoropropane gas used in the Optison as a contrast medium. Further studies are necessary to determine the pathologic consequences of Optison's effects on the blood-brain barrier.
Authors:
G Mychaskiw; A E Badr; R Tibbs; B R Clower; J H Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  91     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-10-18     Revised Date:  2008-05-30    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  798-803     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA. gmychaskiw@anesthesia.umsmed.edu
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MeSH Terms
Descriptor/Qualifier:
Albumins / administration & dosage,  pharmacokinetics,  pharmacology*
Analysis of Variance
Animals
Blood Pressure / drug effects
Blood-Brain Barrier / drug effects*
Brain / blood supply,  pathology
Capillaries / drug effects,  pathology
Carotid Arteries
Cerebrovascular Circulation / drug effects
Coloring Agents / diagnostic use
Contrast Media / administration & dosage,  pharmacokinetics,  pharmacology*
Dose-Response Relationship, Drug
Echocardiography
Evans Blue / diagnostic use
Fluorocarbons / administration & dosage,  pharmacokinetics,  pharmacology*
Gases
Heart Defects, Congenital / ultrasonography
Injections, Intra-Arterial
Male
Microspheres
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Albumins; 0/Coloring Agents; 0/Contrast Media; 0/FS 069; 0/Fluorocarbons; 0/Gases; 314-13-6/Evans Blue; 76-19-7/perflutren

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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