Document Detail

Options for the pharmacotherapy of toxoplasmosis during pregnancy.
MedLine Citation:
PMID:  11584994     Owner:  NLM     Status:  MEDLINE    
Toxoplasmosis infection during pregnancy can cause stillbirths, severe mental retardations or ocular disorders that can also occur later in life and have a potential to relapse. As the disease is generally asymptomatic, diagnosis relies on serological tests. Primary prevention intends to prevent the infection of the fetus, while secondary prevention aims at reducing the severity of sequelae. Preventive attitudes regarding congenital toxoplasmosis differ according to countries. In Austria and France, a nationwide programme based on the screening of seronegative pregnant women and the treatment of all seroconversions has been implemented. The UK and Norway have rejected such a screening due to the lack of evidence of its efficacy. A review of published studies showed that no randomised controlled trials have been conducted. The only available data come from retrospective studies and are methodologically flawed. The impact of chemotherapy on primary and secondary prevention still needs to be assessed. This lack of evidence results in conflicting attitudes that increase the anxiety already raised in pregnant women and doctors by the occurrence of a maternal toxoplasmosis during pregnancy. Before making any change in preventative strategy, it is of utmost importance to increase our knowledge on treatment efficacy through proper randomised trials of existing drugs and of new potentially active compounds.
F Peyron; M Wallon
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on pharmacotherapy     Volume:  2     ISSN:  1465-6566     ISO Abbreviation:  Expert Opin Pharmacother     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-10-04     Completed Date:  2001-12-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100897346     Medline TA:  Expert Opin Pharmacother     Country:  England    
Other Details:
Languages:  eng     Pagination:  1269-74     Citation Subset:  IM    
Service de Parasitologie et de Pathologie Exotique, Hĵpital de la Croix Rousse, Lyon, France.
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MeSH Terms
Antiprotozoal Agents / therapeutic use*
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Complications, Parasitic / drug therapy*
Toxoplasmosis / drug therapy*
Toxoplasmosis, Congenital / drug therapy*,  prevention & control
Reg. No./Substance:
0/Antiprotozoal Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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