Document Detail


Optimum treatment of intracellular infection.
MedLine Citation:
PMID:  8799684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The intracellular location of some micro-organisms has been early recognised as a critical point to explain failure of antibiotic therapy to eradicate such pathogens from infected hosts. Most often parasites invade 'professional' phagocytic cells, including neutrophils, monocytes and macrophages, by resisting the intracellular bactericidal phagolysosomal pathway. Alternatively, they may invade 'non-professional' phagocytic cells (cells with fewer phagocytic and bactericidal abilities) such as endothelial cells, or even cells without lysosomes such as erythrocytes. The intracellular activity of an antibiotic depends on several factors including its ability to reach the eukaryotic cell membrane, its subcellular localisation as compared to that of the parasite, the possibility that the intracellular milieu may partially inactivate its activity, and the susceptibility of the intracellular form of the parasite. In vitro and animal models have been developed to investigate antibiotic activity against intracellular pathogens. However, it should be emphasised that only data obtained from patients give reliable information to define the optimum antibiotic regimen.
Authors:
M Maurin; D Raoult
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Publication Detail:
Type:  In Vitro; Journal Article; Review    
Journal Detail:
Title:  Drugs     Volume:  52     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-11-14     Completed Date:  1996-11-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  NEW ZEALAND    
Other Details:
Languages:  eng     Pagination:  45-59     Citation Subset:  IM    
Affiliation:
Unité des Rickettsies, Faculté de Médecine de la Timone, Marseille, France.
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MeSH Terms
Descriptor/Qualifier:
Alphaproteobacteria
Animals
Anti-Bacterial Agents / therapeutic use*
Bacteria / drug effects*
Bacterial Infections / drug therapy*,  microbiology
Bacterial Physiological Phenomena
Drug Therapy, Combination / therapeutic use
Humans
Microbial Sensitivity Tests
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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