| Optimum number of oocytes for a successful first IVF treatment cycle. | |
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MedLine Citation:
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PMID: 17007663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ovarian stimulation in IVF allows selection of embryos for transfer, but may have detrimental effects on oocyte and embryo quality and endometrial receptivity. This study investigated the optimal response to ovarian stimulation in terms of number of oocytes for achieving pregnancy in a first IVF cycle. Data from 7422 women who underwent their first IVF cycle for standard indications were analysed. All had been treated with exogenous gonadotrophins and gonadotrophin releasing hormone (GnRH) agonist co-treatment in a long down-regulation protocol between 1990 and 1995. Pregnancy rates in relation to the number of obtained oocytes were adjusted for age, fecundity, subfertility cause, gonadotrophin dosage, type of luteal support, and number of transferred embryos by multivariate analysis. Of the 7422 women who underwent oocyte retrieval, overall 85% had an embryo transfer and 24% conceived. The highest pregnancy rates per embryo transfer and per started cycle were observed when 13 oocytes were obtained (31 and 28%, respectively). This study supports the concept of an optimal range of oocytes obtained in response to ovarian stimulation for IVF, below and above which outcomes are compromised. |
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Authors:
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M H van der Gaast; M J C Eijkemans; J B van der Net; E J de Boer; C W Burger; F E van Leeuwen; B C J M Fauser; N S Macklon |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Reproductive biomedicine online Volume: 13 ISSN: 1472-6483 ISO Abbreviation: Reprod. Biomed. Online Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-09-29 Completed Date: 2006-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101122473 Medline TA: Reprod Biomed Online Country: England |
Other Details:
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Languages: eng Pagination: 476-80 Citation Subset: IM |
Affiliation:
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Erasmus Medical Center, Center of Reproductive Medicine, 3015 GD Rotterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cell Count Female Fertilization in Vitro / methods* Humans Middle Aged Oocytes / physiology* Ovulation Induction / methods Pregnancy Pregnancy Rate Retrospective Studies |
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