Document Detail


Optimizing the dose of intrathecal morphine in older patients undergoing hip arthroplasty.
MedLine Citation:
PMID:  14633547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPLICATIONS: The dosage of intrathecal morphine that provides the best balance between analgesic efficacy and side effect profile in the older patient undergoing hip arthroplasty is not known. This prospective, randomized, controlled, double-blinded clinical trial demonstrates that a dose of 100 microg of intrathecal morphine provides the best balance between efficacy and side effects, compared with doses of 0, 50, and 200 microg of morphine, in this patient population.
Authors:
P M Murphy; D Stack; B Kinirons; J G Laffey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  97     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-24     Completed Date:  2003-12-17     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1709-15     Citation Subset:  AIM; IM    
Affiliation:
Department of Anaesthesia, Merlin Park Regional Hospital, Galway, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Analgesics, Opioid / administration & dosage*,  adverse effects,  therapeutic use*
Anesthesia, General
Arthroplasty, Replacement, Hip*
Double-Blind Method
Female
Humans
Injections, Spinal
Male
Morphine / administration & dosage*,  adverse effects,  therapeutic use*
Pain Measurement
Pain, Postoperative / drug therapy*
Postoperative Nausea and Vomiting / epidemiology
Respiratory Function Tests
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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