| Optimizing Molecular Weight of Oat β-Glucan for In Vitro Bile-Acid Binding and Fermentation. | |
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MedLine Citation:
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PMID: 21834529 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Our previous study showed β-glucan with low molecular weight (MW, 1.56 × 10<sup>5</sup> g/mol) bound more bile acid and produced greater amounts of short-chain fatty acids (SCFA) than did -glucan with high MW (Mn = 6.87 × 10<sup>5</sup> g/mol). In the current study, β-glucan extracted from oat flour was fractionated into six different MW levels (high MW: 7.09 × 10<sup>5</sup>, low1 (L1): 3.48 × 10<sup>5</sup> , L2: 2.42 × 10<sup>5</sup>, L3: 1.61 × 10<sup>5</sup>, L4: 0.87 × 10<sup>5</sup>, and L5: 0.46 × 10<sup>5</sup> g/mol) and evaluated to find the optimum MW impacting in vitro bile-acid binding and fermentation. The β-glucan fractions with 2.42 × 10<sup>5</sup> to 1.61 × 10<sup>5</sup> g/mol (L2 and L3) bound the greatest amounts of bile acid. After 24 h fermentation, no differences were found in total SCFA formation among L1, L2, L3, and L4 fractions; however, high MW and L5 MW fractions produced lower amounts of total SCFA. Thus, the optimum MW of β-glucan to impact both hypocholesterolemic and antitumorigenic in vitro effects was in the range of 2.42 × 10<sup>5</sup> to 1.61 × 10<sup>5</sup> g/mol. This MW range also was the most water soluble among the MW evaluated. |
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Authors:
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Hyun Jung Kim; Pamela White |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-10 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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