Document Detail


Optimizing Cardiac Repair and Regeneration Through Activation of the Endogenous Cardiac Stem Cell Compartment.
MedLine Citation:
PMID:  22688972     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Given the aging of the Western World and declining death rates due to acute coronary syndromes, the increasing trends in the magnitude and morbidity of heart failure (HF) are predicted to continue for the foreseeable future. It is imperative to develop effective therapies for the amelioration and prevention of HF. The search for the best cell type to be used in clinical protocols of cardiac regeneration is still on. That the adult mammalian heart harbors endogenous, multipotent cardiac stem/progenitor cells (eCSCs) and that cardiomyocytes are replaced throughout adulthood represent a paradigm shift in cardiovascular biology. The presence of eCSCs supports the view that the heart can repair itself if the eCSCs can be properly stimulated. Pending a better understanding of eCSC biology, it should be possible to replace autologous cell transplantation-based myocardial regeneration protocols with an "off-the-shelf," readily available, and effective regenerative/reparative therapy based on activation of the eCSCs in situ.
Authors:
Georgina M Ellison; Bernardo Nadal-Ginard; Daniele Torella
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-12
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  -     ISSN:  1937-5395     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Stem Cell & Regenerative Biology Unit (BioStem), RISES, Liverpool John Moores University, Room 1.41 Tom Reilly Building, Byrom Street, Liverpool, L3 3AF, UK, G.M.Ellison@ljmu.ac.uk.
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