Document Detail


Optimized ventricular restraint therapy: adjustable restraint is superior to standard restraint in an ovine model of ischemic cardiomyopathy.
MedLine Citation:
PMID:  22698557     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The effects of ventricular restraint level on left ventricular reverse remodeling are not known. We hypothesized that restraint level affects the degree of reverse remodeling and that restraint applied in an adjustable manner is superior to standard, nonadjustable restraint.
METHODS: This study was performed in 2 parts using a model of chronic heart failure in the sheep. In part I, restraint was applied at control (0 mm Hg, n = 3), low (1.5 mm Hg, n = 3), and high (3.0 mm Hg, n = 3) levels with an adjustable and measurable ventricular restraint (AMVR) device. Restraint level was not altered throughout the 2-month treatment period. Serial restraint level measurements and transthoracic echocardiography were performed. In part II, restraint was applied with the AMVR device set at 3.0 mm Hg (n = 6) and adjusted periodically to maintain that level. This was compared with restraint applied in a standard, nonadjustable manner using a mesh wrap (n = 6). All subjects were followed up for 2 months with serial magnetic resonance imaging.
RESULTS: In part I, there was greater and earlier reverse remodeling in the high restraint group. In both groups, the rate of reverse remodeling peaked and then declined as the measured restraint level decreased with progression of reverse remodeling. In part II, adjustable restraint resulted in greater reverse remodeling than standard restraint. Left ventricular end diastolic volume decreased by 12.7% (P = .005) with adjustable restraint and by 5.7% (P = .032) with standard restraint. Left ventricular ejection fraction increased by 18.9% (P = .014) and 14.4% (P < .001) with adjustable and standard restraint, respectively.
CONCLUSIONS: Restraint level affects the rate and degree of reverse remodeling and is an important determinant of therapy efficacy. Adjustable restraint is more effective than nonadjustable restraint in promoting reverse remodeling.
Authors:
Lawrence S Lee; Ravi K Ghanta; Suyog A Mokashi; Otavio Coelho-Filho; Raymond Y Kwong; Michael Kwon; Jian Guan; Ronglih Liao; Frederick Y Chen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-12
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  145     ISSN:  1097-685X     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-05-16     Revised Date:  2014-03-28    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  824-31     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / metabolism
Disease Models, Animal
Echocardiography
Heart Failure / physiopathology,  surgery*
Heart Function Tests
Heart Ventricles / physiopathology,  surgery*
Ligation
Magnetic Resonance Imaging
Matrix Metalloproteinase 2 / metabolism
Natriuretic Peptide, Brain / blood
Sheep, Domestic
Ventricular Remodeling*
Grant Support
ID/Acronym/Agency:
F32HL080904/HL/NHLBI NIH HHS; F32HL104923/HL/NHLBI NIH HHS; R01 HL091157/HL/NHLBI NIH HHS; R01HL090862/HL/NHLBI NIH HHS; R01HL091157/HL/NHLBI NIH HHS; R01HL102786/HL/NHLBI NIH HHS; R01HL102791/HL/NHLBI NIH HHS; R01HL10378/HL/NHLBI NIH HHS; T32HL076130/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 114471-18-0/Natriuretic Peptide, Brain; EC 3.4.24.24/Matrix Metalloproteinase 2
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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