Document Detail

Optimized quantitative angiographic and intravascular ultrasound parameters predicting the functional significance of single de novo lesions in the left anterior descending artery.
MedLine Citation:
PMID:  23217395     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: The correlation between angiographic or intravascular ultrasound (IVUS) variables and fractional flow reserve (FFR) in patients with single left anterior descending artery (LAD) lesion has not been studied. The current study aimed at determining the best cutoff value of angiographic and IVUS parameters for defining FFR < 0.80 in patients with LAD lesion.
METHODS: Quantitative coronary analysis, IVUS and FFR measurements were undergone in 169 patients with single LAD lesion. The best angiographic and IVUS cutoff value and their predictive value for FFR < 0.80 were compared using area under the receiver-operator characteristic curve (AUC) in overall patients or in subgroups stratified by lesion sites.
RESULTS: FFR < 0.80 was found in 99 lesions (58.6%). Minimal lumen area (MLA), and plaque burden (PB) were two predictors of FFR < 0.80. Lesion length had less value in predicting FFR < 0.80. The cutoff value of PB and MLA for FFR < 0.80 was 75.4% and 3.03 mm(2). MLA and PB had similar high diagnostic value for proximal (cutoff value 3.04 mm(2) and 76.5%) and distal LAD lesion (2.82 mm(2) and 80.6%). Combination of MLA (2.82 mm(2)) and PB (80.6%) had increased diagnostic value for distal LAD lesion.
CONCLUSIONS: MLA and plaque burden had equivalent diagnostic value for FFR < 0.80 when lesion localized in LAD. The predictive value of combination of MLA and plaque burden for distal LAD lesion was strengthened.
Tak W Kwan; Song Yang; Bo Xu; Jack Chen; Tian Xu; Fei Ye; Jun-Jie Zhang; Nai-Liang Tian; Zhi-Zhong Liu; Shao-Liang Chen
Related Documents :
16222165 - Bronchiectasis in persons with skin lesions resulting from arsenic in drinking water.
24262235 - 15. evaluation of anal cytology versus high-resolution anoscopy (hra) in the diagnosis ...
23328975 - Flat pattern of nephrogenic adenoma: previously unrecognized pattern unveiled using pax...
17515515 - Fluoroscopy-induced chronic radiation skin injury: a disease perhaps often overlooked.
23442735 - Classification, morphology and molecular pathology of premalignant lesions of the pancr...
14568685 - The diagnostic yield of transbronchial needle aspiration in superior vena cava syndrome.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  125     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  4249-53     Citation Subset:  IM    
Beth Israel Medical Center, NY, New York, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interleukin-18 and -12 synergistically enhance cytotoxic functions of tumor-infiltrating lymphocytes...
Next Document:  Increased expression of osteopontin in brain arteriovenous malformations.