Document Detail

Optimized photodynamic therapy with systemic photosensitizer following debulking technique for nonmelanoma skin cancers.
MedLine Citation:
PMID:  17300605     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The thickness and depth of invasion of skin tumors may be limiting factors for topical photosensitizer-based photodynamic therapy (PDT). The use of PDT with systemic photosensitizer needs to be further explored as a modality of treatment for nonmelanoma skin cancer (NMSC). OBJECTIVE: The objective was to present six patients with multiple, nodular, and/or pigmented NMSC treated successfully with purified hematoporphyrin derivative (PHD) and PDT using prior debulking. METHODS: After 24 hours of systemic PHD (1.5 mg/kg), 12 lesions of NMSC were selected for PHD-PDT alone and 6 nodular/elevated lesions for PHD-PDT following a debulking procedure. The tumor area was illuminated in one single-dose session of 300 J/cm(2), at an intensity range of 130 to 150 mW/cm(2), with a 630-nm-wavelength diode laser. RESULTS: The prior curettage provided significant reduction in volume and/or pigmentation of lesions. After the session of PHD-PDT with prior curettage and additional topical 20% ALA-PDT in two lesions or PHD-PDT alone, 83% (5/6) of lesions and 58% (7/12) of lesions, respectively, maintained a complete clinical response, 22.2+/-8.9 months of follow-up. CONCLUSIONS: The combination of prior debulking with systemic agents-PDT appears to be a good option for multiple, pigmented, and/or nodular lesions of NMSC and can allow the improvement of clinical results.
Cacilda S Souza; Ana B S Neves; Lília A B Felício; Juliana Ferreira; Cristina Kurachi; Vanderlei S Bagnato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  33     ISSN:  1076-0512     ISO Abbreviation:  Dermatol Surg     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-15     Completed Date:  2007-03-15     Revised Date:  2007-04-25    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  194-8     Citation Subset:  IM    
Division of Dermatology of the School of Medicine of Ribeirão Preto, University of São Paulo, São Carlos, São Paulo, Brazil.
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MeSH Terms
Aged, 80 and over
Facial Dermatoses / drug therapy*,  surgery
Middle Aged
Photochemotherapy / methods*
Photosensitizing Agents / therapeutic use*
Skin Neoplasms / drug therapy*,  surgery
Treatment Outcome
Reg. No./Substance:
0/Photosensitizing Agents
Erratum In:
Dermatol Surg. 2007 Apr;33(4):523

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