Document Detail

Optimized hyperventilation preserves 2,3-diphosphoglycerate in severe traumatic brain injury.
MedLine Citation:
PMID:  17952273     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The concentration of 2,3-diphosphoglycerate (2,3-DPG/Hct) increases as a physiological occurrence to pH increase and hyperventilation. This response was tested in patients with severe traumatic brain injury (TBI). METHOD: The concentration of 2,3-DPG/Hct was measured daily for six days in eleven patients with severe TBI in need of optimized hyperventilation because of intracranial hypertension. RESULTS: There was correlation between pH and the concentration of DPG/Hct. The concentration of 2,3-DPG/Hct remained predominantly within normal levels with slight increase in the sixth day of the study. The concentration of 2,3-DPG/Hct correlated significantly with measured partial pressure of oxygen that saturates 50% the hemoglobin of the blood (P50st), confirming the consistency of our data. CONCLUSION: The expected physiological response of a progressive increase in concentration of 2,3-DPG/Hct to hyperventilation was not observed. This fact may be explained by the intermittent and not sustained hyperventilation as dictated by the protocol of optimized ventilation.
Rayne Borges Torres; Renato Giuseppe Giovanni Terzi; Antônio Luís Eiras Falcão; Nelci Fenalti Höehr; Venâncio Pereira Dantas Filho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arquivos de neuro-psiquiatria     Volume:  65     ISSN:  0004-282X     ISO Abbreviation:  Arq Neuropsiquiatr     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2008-05-01     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0125444     Medline TA:  Arq Neuropsiquiatr     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  739-44     Citation Subset:  IM    
Campinas State University, Campinas, São Paulo, Brazil.
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MeSH Terms
2,3-Diphosphoglycerate / blood*
Blood Gas Analysis
Brain Injuries / blood*,  therapy
Case-Control Studies
Erythrocytes / chemistry
Glasgow Coma Scale
Middle Aged
Respiration, Artificial*
Reg. No./Substance:

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