| Optimized hyperventilation preserves 2,3-diphosphoglycerate in severe traumatic brain injury. | |
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MedLine Citation:
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PMID: 17952273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The concentration of 2,3-diphosphoglycerate (2,3-DPG/Hct) increases as a physiological occurrence to pH increase and hyperventilation. This response was tested in patients with severe traumatic brain injury (TBI). METHOD: The concentration of 2,3-DPG/Hct was measured daily for six days in eleven patients with severe TBI in need of optimized hyperventilation because of intracranial hypertension. RESULTS: There was correlation between pH and the concentration of DPG/Hct. The concentration of 2,3-DPG/Hct remained predominantly within normal levels with slight increase in the sixth day of the study. The concentration of 2,3-DPG/Hct correlated significantly with measured partial pressure of oxygen that saturates 50% the hemoglobin of the blood (P50st), confirming the consistency of our data. CONCLUSION: The expected physiological response of a progressive increase in concentration of 2,3-DPG/Hct to hyperventilation was not observed. This fact may be explained by the intermittent and not sustained hyperventilation as dictated by the protocol of optimized ventilation. |
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Authors:
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Rayne Borges Torres; Renato Giuseppe Giovanni Terzi; Antônio Luís Eiras Falcão; Nelci Fenalti Höehr; Venâncio Pereira Dantas Filho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arquivos de neuro-psiquiatria Volume: 65 ISSN: 0004-282X ISO Abbreviation: Arq Neuropsiquiatr Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-10-22 Completed Date: 2008-05-01 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0125444 Medline TA: Arq Neuropsiquiatr Country: Brazil |
Other Details:
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Languages: eng Pagination: 739-44 Citation Subset: IM |
Affiliation:
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Campinas State University, Campinas, São Paulo, Brazil. raynebt@yahoo.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2,3-Diphosphoglycerate
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blood* APACHE Adolescent Adult Blood Gas Analysis Brain Injuries / blood*, therapy Case-Control Studies Child Erythrocytes / chemistry Female Glasgow Coma Scale Humans Male Middle Aged Respiration, Artificial* |
| Chemical | |
Reg. No./Substance:
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138-81-8/2,3-Diphosphoglycerate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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