| Optimized enzymatic synthesis of hesperidin Fatty Acid esters in a two-phase system containing ionic liquid. | |
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MedLine Citation:
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PMID: 21862958 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Response surface methodology (RSM) based on a five-level, three-variable central composite design (CCD) was employed for modeling and optimizing the conversion yield of the enzymatic acylation of hesperidin with decanoic acid using immobilized Candida antarctica lipase B (CALB) in a two-phase system containing [bmim]BF(4). The three variables studied (molar ratio of hesperidin to decanoic acid, [bmim]BF(4)/acetone ratio and lipase concentration) significantly affected the conversion yield of acylated hesperidin derivative. Verification experiments confirmed the validity of the predicted model. The lipase showed higher conversion degree in a two-phase system using [bmim]BF(4) and acetone compared to that in pure acetone. Under the optimal reaction conditions carried out in a single-step biocatalytic process when the water content was kept lower than 200 ppm, the maximum acylation yield was 53.6%. |
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Authors:
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Maria Elisa Melo Branco de Araújo; Fabiano Jares Contesini; Yollanda Edwirges Moreira Franco; Alexandra C H Frankland Sawaya; Thiago Grando Alberto; Natália Dalfré; Patrícia de Oliveira Carvalho |
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Publication Detail:
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Type: Journal Article Date: 2011-08-23 |
Journal Detail:
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Title: Molecules (Basel, Switzerland) Volume: 16 ISSN: 1420-3049 ISO Abbreviation: Molecules Publication Date: 2011 |
Date Detail:
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Created Date: 2011-08-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100964009 Medline TA: Molecules Country: Switzerland |
Other Details:
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Languages: eng Pagination: 7171-82 Citation Subset: IM |
Affiliation:
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São Francisco University, São Francisco de Assis Av., 218, Bragança Paulista, SP 12916-900, Brazil. patcarvalho@saofrancisco.edu.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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