| Optimized double inversion recovery for reduction of T(1) weighting in fluid-attenuated inversion recovery. | |
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MedLine Citation:
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PMID: 21590725 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Fluid-attenuated inversion recovery (FLAIR) is a routinely used technique in clinical practice to detect long T(2) lesions by suppressing the cerebrospinal fluid. Concerns remain, however, that the inversion pulse in FLAIR imparts T(1) weighting that can decrease the detectability and mischaracterize some lesions. Hence, FLAIR is usually acquired in conjunction with a standard T(2) to guard against these concerns. Recently, double inversion recovery (DIR) preparations have highlighted certain types of lesions by suppressing both cerebrospinal fluid and white matter but produce even stronger T(1) contrast than FLAIR. This work shows that the inversion times in a DIR sequence can be optimized to minimize unwanted T(1) weighting, enabling the acquisition of cerebrospinal fluid-suppressed images with pure T(2) weighting. This technique is referred to as T(1) -nulled DIR. The theory to determine the optimized inversion times is discussed and the results are shown by simulations, normal volunteer studies, and multiple sclerosis patient studies. T(1) -nulled DIR provides equivalent or superior contrast between gray and white matters as well as white matter and multiple sclerosis lesion at the same repetition time. Multiple sclerosis lesions appeared sharper on T(1) -nulled DIR compared to FLAIR. T(1) -nulled DIR has the potential to replace the combination of standard T(2) and FLAIR acquisitions in many clinical protocols. Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc. |
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Authors:
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Ananth J Madhuranthakam; Subhendra N Sarkar; Reed F Busse; Rohit Bakshi; David C Alsop |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-16 |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: - ISSN: 1522-2594 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Global Applied Science Lab, GE Healthcare, Boston, Massachusetts, USA. ananth.madhuranthakam@ge.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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