Document Detail

Optimization and validation of a fully-integrated pulse sequence for modified look-locker inversion-recovery (MOLLI) T1 mapping of the heart.
MedLine Citation:
PMID:  17896383     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To optimize and validate a fully-integrated version of modified Look-Locker inversion-recovery (MOLLI) for clinical single-breathhold cardiac T1 mapping. MATERIALS AND METHODS: A MOLLI variant allowing direct access to all pulse sequence parameters was implemented on a 1.5T MR system. Varying four critical sequence parameters, MOLLI was performed in eight gadolinium-doped agarose gel phantoms at different simulated heart rates. T1 values were derived for each variant and compared to nominal T1 values. Based on the results, MOLLI was performed in midcavity short-axis views of 20 healthy volunteers pre- and post-Gd-DTPA. RESULTS: In phantoms, a readout flip angle of 35 degrees , minimum TI of 100 msec, TI increment of 80 msec, and use of three pausing heart cycles allowed for most accurate and least heart rate-dependent T1 measurements. Using this pulse sequence scheme in humans, T1 relaxation times in normal myocardium were comparable to data from previous studies, and showed narrow ranges both pre- and postcontrast without heart rate dependency. CONCLUSION: We present an optimized implementation of MOLLI for fast T1 mapping with high spatial resolution, which can be integrated into routine imaging protocols. T1 accuracy is superior to the original set of pulse sequence parameters and heart rate dependency is avoided.
Daniel R Messroghli; Andreas Greiser; Mirko Fröhlich; Rainer Dietz; Jeanette Schulz-Menger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  26     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1081-6     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Cardiac MRI Unit, Franz-Volhard-Klinik, Charité Campus Buch, Universitätsmedizin Berlin, Helios-Klinikum Berlin, Germany.
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MeSH Terms
Contrast Media / pharmacology
Gadolinium / pharmacology*
Gadolinium DTPA / pharmacology
Heart / anatomy & histology*
Heart Rate
Image Processing, Computer-Assisted
Magnetic Resonance Imaging / methods
Myocardium / pathology*
Phantoms, Imaging
Reproducibility of Results
Time Factors
Reg. No./Substance:
0/Contrast Media; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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