Document Detail

Optimization of thickness, pore size and mechanical properties of a biomaterial designed for deep burn coverage.
MedLine Citation:
PMID:  10147169     Owner:  NLM     Status:  MEDLINE    
A collagen and chondroitins 4-, 6-sulphate biomaterial designed for the coverage of severe burns was optimized in terms of mechanical strength by addition of 20% (wt/vol) of chitosan to the starting material. Chitosan should create ionic bonds with collagen and thus increase the tensile strength and Young's modulus of the sponge. On the other hand, sterilization by h-irradiation of the biomaterial induced a decrease in its mechanical properties that could be avoided by sterilization using beta-irradiation. The thickness, pore size and morphology of the biomaterial were optimized before freeze-drying by freezing the mixture at -60 degrees C at a weight/volume concentration of 1.25% and a volume of 270 mul/cm2. The biomaterial obtained under these conditions may further the vascularization and cellular colonization of the porous structure by the host cells of the wound bed and therefore may accelerate the regeneration of a new dermis.
F Berthod; G Saintigny; F Chretien; D Hayek; C Collombel; O Damour
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical materials     Volume:  15     ISSN:  0267-6605     ISO Abbreviation:  Clin Mater     Publication Date:  1994  
Date Detail:
Created Date:  1994-08-25     Completed Date:  1994-08-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8707278     Medline TA:  Clin Mater     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  259-65     Citation Subset:  T    
Hôpital Edouard Herriot, Service de Biochimie C, Laboratoire des Substituts Cutanés, Lyon, France.
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MeSH Terms
Burns / therapy*
Chitin / analogs & derivatives
Chondroitin Sulfates / therapeutic use*
Collagen / radiation effects,  therapeutic use*
Materials Testing
Microscopy, Electron, Scanning
Skin, Artificial*
Sterilization / methods
Tensile Strength
Wound Healing
Reg. No./Substance:
1398-61-4/Chitin; 9007-28-7/Chondroitin Sulfates; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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