| Optimization of thickness, pore size and mechanical properties of a biomaterial designed for deep burn coverage. | |
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MedLine Citation:
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PMID: 10147169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A collagen and chondroitins 4-, 6-sulphate biomaterial designed for the coverage of severe burns was optimized in terms of mechanical strength by addition of 20% (wt/vol) of chitosan to the starting material. Chitosan should create ionic bonds with collagen and thus increase the tensile strength and Young's modulus of the sponge. On the other hand, sterilization by h-irradiation of the biomaterial induced a decrease in its mechanical properties that could be avoided by sterilization using beta-irradiation. The thickness, pore size and morphology of the biomaterial were optimized before freeze-drying by freezing the mixture at -60 degrees C at a weight/volume concentration of 1.25% and a volume of 270 mul/cm2. The biomaterial obtained under these conditions may further the vascularization and cellular colonization of the porous structure by the host cells of the wound bed and therefore may accelerate the regeneration of a new dermis. |
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Authors:
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F Berthod; G Saintigny; F Chretien; D Hayek; C Collombel; O Damour |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical materials Volume: 15 ISSN: 0267-6605 ISO Abbreviation: Clin Mater Publication Date: 1994 |
Date Detail:
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Created Date: 1994-08-25 Completed Date: 1994-08-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8707278 Medline TA: Clin Mater Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 259-65 Citation Subset: T |
Affiliation:
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Hôpital Edouard Herriot, Service de Biochimie C, Laboratoire des Substituts Cutanés, Lyon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Burns
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therapy* Chitin / analogs & derivatives Chondroitin Sulfates / therapeutic use* Collagen / radiation effects, therapeutic use* Freezing Humans Materials Testing Microscopy, Electron, Scanning Porosity Skin, Artificial* Sterilization / methods Tensile Strength Wound Healing |
| Chemical | |
Reg. No./Substance:
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1398-61-4/Chitin; 9007-28-7/Chondroitin Sulfates; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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