| Optimization of succinic acid fermentation with Actinobacillus succinogenes by response surface methodology (RSM). | |
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MedLine Citation:
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PMID: 22302423 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Succinic acid is considered as an important platform chemical. Succinic acid fermentation with Actinobacillus succinogenes strain BE-1 was optimized by central composite design (CCD) using a response surface methodology (RSM). The optimized production of succinic acid was predicted and the interactive effects between glucose, yeast extract, and magnesium carbonate were investigated. As a result, a model for predicting the concentration of succinic acid production was developed. The accuracy of the model was confirmed by the analysis of variance (ANOVA), and the validity was further proved by verification experiments showing that percentage errors between actual and predicted values varied from 3.02% to 6.38%. In addition, it was observed that the interactive effect between yeast extract and magnesium carbonate was statistically significant. In conclusion, RSM is an effective and useful method for optimizing the medium components and investigating the interactive effects, and can provide valuable information for succinic acid scale-up fermentation using A. succinogenes strain BE-1. |
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Authors:
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Yun-Jian Zhang; Qiang Li; Yu-Xiu Zhang; Dan Wang; Jian-Min Xing |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Zhejiang University. Science. B Volume: 13 ISSN: 1862-1783 ISO Abbreviation: J Zhejiang Univ Sci B Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101236535 Medline TA: J Zhejiang Univ Sci B Country: China |
Other Details:
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Languages: eng Pagination: 103-10 Citation Subset: IM |
Affiliation:
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School of Chemical and Environmental Engineering, China University of Mining and Technology (Beijing), Beijing 100083, China; State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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