| Optimization of single injection liver arterial phase gadolinium enhanced MRI using bolus track real-time imaging. | |
| | |
MedLine Citation:
|
PMID: 21182128 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
PURPOSE: To measure contrast agent enhancement kinetics in the liver and to further evaluate and develop an optimized gadolinium enhanced MRI using a single injection real-time bolus-tracking method for reproducible imaging of the transient arterial-phase. MATERIALS AND METHODS: A total of 18 subjects with hypervascular liver lesions were imaged with four dimensional (4D) perfusion scans to measure time-to-peak (TTP) delays of arterial (aorta-celiac axis), liver parenchyma, liver lesion, portal, and hepatic veins. Time delays were calculated from the TTP-aorta signal, and then related to the gradient echo (GRE) k-space acquisition design, to determine optimized timing for real-time bolus-track triggering methodology. As another measure of significance, 200 clinical patients were imaged with 3D-GRE using either a fixed time-interval or by individualized arterial bolus real-time triggering. Bolus TTP-aorta was calculated and arterial-phase acquisitions were compared for accuracy and reproducibility using specific vascular enhancement indicators. RESULTS: The mean bolus transit-time to peak-lesion contrast was 8.1 ± 2.7 seconds following arterial detection, compared to 32.1 ± 5.4 seconds from contrast injection, representing a 62.1% reduction in the time-variability among subjects (N = 18). The real-time bolus-triggered technique more consistently captured the targeted arterial phase (94%), compared to the fixed timing technique (73%), representing an expected improvement of timing accuracy in 28% of patients (P = 0.0001389). CONCLUSION: Our results show detailed timing window analysis required for optimized arterial real-time bolus-triggering acquisition of transient arterial phase features of liver lesions, with optimized arterial triggering expected to improve reproducibility in a significant number of patients. |
| | |
Authors:
|
Puneet Sharma; Bobby Kalb; Hiroumi D Kitajima; Khalil N Salman; Bobbie Burrow; Gaye L Ray; Diego R Martin |
Related Documents
:
|
9725448 - Cavopulmonary anastomosis in staging toward fontan operation: pathologic substrates. 15172288 - Congenitally corrected transposition: size of the pulmonary trunk and septal malalignment. 7352398 - Crossed atrioventricular connections. 4080578 - An unusual complication of a conduit-mounted homograft: valve leaflet fixation in the o... 9918508 - Electrophoretic and chromatographic patterns of glycosaminoglycans of the umbilical cor... 22782498 - Successful endovascular management of brain aneurysms presenting with mass effect and c... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of magnetic resonance imaging : JMRI Volume: 33 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 110-8 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
|
Department of Radiology, Emory Healthcare, Inc., Atlanta, Georgia, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Correlation of the apparent diffusion coefficient value and dynamic magnetic resonance imaging findi...
Next Document: Liver methylene fraction by dual- and triple-echo gradient-echo imaging at 3.0T: Correlation with pr...