| Optimization and robustness of blood tests for liver fibrosis and cirrhosis. | |
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MedLine Citation:
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PMID: 20713037 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To optimize the performance and feasibility of fibrosis blood tests and evaluate their robustness. DESIGN AND METHODS: The derivation population included 1056 HCV patients with liver biopsy and blood markers. Validation populations included 984 patients with various viral hepatitis causes, and Fibroscan and/or liver biopsy and/or blood markers. RESULTS: The bootstrap method validated the markers of the original FibroMeter(2G), but not those of Fibrotest and Hepascore, and provided a hyaluronate-free FibroMeter(3G). AUROCs for significant fibrosis were: FibroMeter(2G): 0.853 vs. FibroMeter(3G): 0.851, p=0.489. Compared to FibroMeter(2G), FibroMeter(3G) had a significantly higher patient rate with predictive values ≥90% for significant fibrosis. Accuracy for fibrosis stage classification was: Fibrotest: 37.9%, FibroMeter(2G): 74.9%, and FibroMeter(3G): 86.9% (p<10(-3)). CONCLUSION: The bootstrap method validated FibroMeter(2G) and provided a cheaper and more feasible hyaluronate-free FibroMeter(3G) with comparable performance. Compared to binary diagnosis, fibrosis stage classification increased discrimination, with an increased accuracy to 87% for FibroMeter(3G). |
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Authors:
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Paul Calès; Jérôme Boursier; Sandrine Bertrais; Frédéric Oberti; Yves Gallois; Isabelle Fouchard-Hubert; Nina Dib; Jean-Pierre Zarski; Marie Christine Rousselet; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-14 |
Journal Detail:
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Title: Clinical biochemistry Volume: 43 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-11 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1315-22 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 The Canadian Society of Clinical Chemist. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Service d'Hépato-Gastroentérologie, CHU, Angers, France. paul.cales@univ-angers.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Area Under Curve Biological Markers / blood HIV Infections / blood, complications Hematologic Tests / methods* Hepatitis C / blood, complications Humans Liver Cirrhosis / blood*, classification, diagnosis ROC Curve Reproducibility of Results Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Investigator | |
Investigator/Affiliation:
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Sophie Michalak / ; Anselme Konaté / ; Catherine Ternisien / ; Alain Chevailler / ; Françoise Lunel / ; Marie Christine Rousselet / ; Wael Mansour / ; Philippe Halfon / ; Marc Bourlière / ; Denis Ouzan / ; Albert Tran / ; Danielle Botta / ; Christophe Renou / ; Christophe Sattonnet / ; Marie-Christine Saint-Paul / ; Thierry Benderitter / ; Stéphane Garcia / ; Henri Pierre Bonneau / ; Guillaume Penaranda / ; Yannick Bacq / ; Anne de Muret / ; Marie-Claude Bréchot / ; Vincent Leroy / ; Nathalie Sturm / ; Marie-Noelle Hilleret / ; Jean-Pierre Zarski / ; Patrice Faure / ; Jean-Charles Renversez / ; Francoise Morel / ; Candice Trocme / ; Victor de Ledinghen / ; Juliette Foucher / ; Laurent Castéra / ; Patrice Couzigou / ; Pierre-Henri Bernard / ; Wassil Merrouche / ; Paulette Bioulac-Sage / ; Brigitte Le Bail / ; Claude Degott / ; Valérie Paradis / ; R Poupon / ; A Poujol / ; A Abergel / ; J P Bronowicki / ; J P Vinel / ; S Metivier / ; V De Ledinghen / ; O Goria / ; M Maynard-Muet / ; C Trepo / ; Ph Mathurin / ; D Guyader / ; H Danielou / ; O Rogeaux / ; S Pol / ; Ph Sogni / ; A Tran / ; P Calès / ; P Marcellin / ; T Asselah / ; M Bourliere / ; V Oulès / ; D Larrey / ; F Habersetzer / ; M Beaugrand / ; V Leroy / ; M N Hilleret / ; R-C Boisson / ; M-C Gelineau / ; B Poggi / ; J-C Renversez / ; Candice Trocmé / ; J Guéchot / ; R Lasnier / ; M Vaubourdolle / ; H Voitot / ; A Vassault / ; A Rosenthal-Allieri / ; A Lavoinne / ; F Ziegler / ; M Bartoli / ; C Lebrun / ; A Myara / ; F Guerber / ; A Pottier / ; E-S Zafrani / ; N Sturm / ; A Bechet / ; J-L Bosson / ; S Royannais / ; A Plages / ; Paul Calès / ; Philippe Halfon / ; Dominique Batisse / ; Fabrice Carrat / ; Philippe Perré / ; Guillaume Penaranda / ; Dominique Guyader / ; Louis d'Alteroche / ; Isabelle Fouchard-Hubert / ; Christian Michelet / ; Pascal Veillon / ; Jérôme Lambert / ; Laurence Weiss / ; Dominique Salmon / ; Patrice Cacoub / ; Maria Winnock / ; Marie Christine Rousselet / ; Françoise Lunel / ; Frédéric Oberti / ; Sandrine Bertrais / ; Gilles Hunault / ; Bruno Vielle / ; Annick Ruffault / ; Anne Gaëlle Kervegant / ; Gwénaëlle Soulard / |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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