| Optimization of the processing of matrix pellets based on the combination of waxes and starch using experimental design. | |
| | |
MedLine Citation:
|
PMID: 9876595 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An experimental design was used in order to optimize the one-step production process of matrix pellets based on the combination of waxes and starch. The parameters tested were the impeller speed (x1) and the mixing time (x2). Ibuprofen and theophylline were used as model drugs at a concentration of 60 and 70% (w/w), respectively. The 0.8-1.25 mm yield fraction of the matrix pellets was evaluated as the response factor Y. A quadratic equation was fitted to the experimental data and used to predict the response factor Y of the theophylline and the ibuprofen. The contour plots of both formulations revealed a flat and therefore rugged region from the upper left to the lower right of the domain investigated. The energy input into the system during the production process controlled the pellet growth, the impeller speed having a greater impact on the energy input compared to the mixing time. |
| | |
Authors:
|
F Zhou; C Vervaet; D L Massart; B Massart; J P Remon |
Related Documents
:
|
21388605 - The theory of planned behavior as a predictor of growth in risky college drinking. 19410445 - Searching quality data for municipal solid waste planning. 20036115 - Estimation of the annual production and composition of c&d debris in galicia (spain). 21230515 - Biodiversity on island chains: neutral model simulations. 21162115 - Non-linear mixed effect modeling of the time-variant disposition of erythropoietin in a... 2674025 - A model-based system to determine the relative value of different variables in a diagno... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Drug development and industrial pharmacy Volume: 24 ISSN: 0363-9045 ISO Abbreviation: Drug Dev Ind Pharm Publication Date: 1998 Apr |
Date Detail:
|
Created Date: 1999-02-01 Completed Date: 1999-02-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7802620 Medline TA: Drug Dev Ind Pharm Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 353-8 Citation Subset: IM |
Affiliation:
|
Laboratory of Pharmaceutical Technology, University of Gent, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Delayed-Action Preparations Drug Compounding / instrumentation, methods* Evaluation Studies as Topic Humans Ibuprofen / administration & dosage Starch Theophylline / administration & dosage Waxes |
| Chemical | |
Reg. No./Substance:
|
0/Delayed-Action Preparations; 0/Waxes; 15687-27-1/Ibuprofen; 58-55-9/Theophylline; 9005-25-8/Starch |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Compatibility evaluation of metered-dose inhaler valve elastomers with tetrafluoroethane (P134a), a ...
Next Document: Alternative solvent-free preparation methods for felodipine surface solid dispersions.